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1- (4'- hydroxy- 2'- butenoxy)methyl- 2- nitroimidazole (RK 28)
structure given in first source
Also Known As:
RK 28
; RK-28
Networked:
4
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Nitro Compounds: 66
Nitroimidazoles: 565
Misonidazole: 539
1-(4'-hydroxy-2'-butenoxy)methyl-2-nitroimidazole: 4
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Imidazoles: 150
Nitroimidazoles: 565
Misonidazole: 539
1-(4'-hydroxy-2'-butenoxy)methyl-2-nitroimidazole: 4
Related Diseases
1.
Pancreatic Neoplasms (Pancreatic Cancer)
08/01/1988 - "
Therefore, RK-28 was effective in the treatment of the experimental pancreatic cancer (the enhancement ratio: 1.37).
"
01/01/1992 - "
To reduce its toxicity and increase its sensitizing activity, intratumoral injection of RK-28 was performed during intraoperative radiation therapy for pancreatic cancer.
"
2.
Neoplasms (Cancer)
01/01/1992 - "
Pharmacokinetic studies demonstrated several metabolites of RK-28 in both serum and tumor tissues.
"
08/01/1988 - "
When combined with 30 or 40 Gy of irradiation, which is applicable to intraoperative irradiation, RK-28 induced a longer period of tumor suppression and a higher tumor regression ratio than irradiation alone.
"
08/01/1988 - "
These results indicate that RK-28 significantly increases the effect of intraoperative irradiation and this combination therapy could possibly induce remarkable effect on tumor regression and long-term survival.
"
01/01/1992 - "
After intratumoral injection, the tumor drug concentration ranged from 123 micrograms/g to 9,292 micrograms/g just after intraoperative radiation therapy (30-50 min after injection of the compound), while the serum concentration ranged from 4.1 to 9.8 micrograms/ml. The tumor drug concentration was 23.3 micrograms/g at 45 min after intravenous injection of RK-28.
"
08/25/1985 - "
[Radiosensitizing effect of new hypoxic cell radiosensitizer, RK-28 on experimental animal normal tissue and Ehrlich tumor].
"
Related Drugs and Biologics
1.
Etanidazole
2.
Radiation-Sensitizing Agents
3.
Nucleosides
4.
Glucose (Dextrose)
5.
KU 2285
6.
RP 170
7.
azomycin
Related Therapies and Procedures
1.
Therapeutics
2.
Radiotherapy
3.
Intravenous Injections