His(5)-Trp(7)-Tyr(8)- LHRH

isolated from chicken hypothalamus; also ostrich; RN given refers to all-(L)-isomer

Also Known As:

LHRH, His(5)-Trp(7)-Tyr(8)-; 5-His-7-Trp-8-Tyr-LHRH; 5-histidyl-7-tryptophyl-8-tyrosine-LHRH; GNRH, chicken II; GnRH, His(5)-Trp(7)-Tyr(8)-; GnRH-II; GnRHII; His(5)-Trp(7)-Tyr(8)-GnRH; LHRH, histidyl(5)-tryptophyl(7)-tyrosine(8)-; LHRH-II; LHRH-II, chicken; cGnRH-II; cLHRH II; p-Glu-His-Trp-Ser-His-Gly-Trp-Tyr-Pro-GlyNH2

Networked: 72 relevant articles (3 outcomes, 25 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Leung, Peter C K: 13 articles (03/2011 - 04/2003)
2.	Emons, Günter: 10 articles (01/2013 - 03/2002)
3.	Gründker, Carsten: 10 articles (01/2013 - 03/2002)
4.	Günthert, Andreas R: 7 articles (01/2010 - 03/2002)
5.	Choi, Kyung-Chul: 6 articles (08/2009 - 06/2004)
6.	Huang, Fengying: 5 articles (01/2013 - 09/2009)
7.	Wang, Huanping: 5 articles (01/2013 - 09/2009)
8.	Auersperg, Nelly: 5 articles (06/2007 - 06/2004)
9.	Zou, Ying: 4 articles (01/2013 - 09/2009)
10.	Eicke, Nicola: 4 articles (11/2006 - 07/2004)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2010 - "These preliminary data suggest that local GnRH-II may participate in the regulation of ovarian tumor growth in post-menopausal women." 03/01/2010 - "The expression of GnRH-II was found to be 1.5 times higher in malignant ovarian tumors compared with benign ovarian tumors and the control group in post-menopausal patients (P<0.01). " 01/01/2010 - "The GnRH-II antagonist inhibited the growth of xenotransplants of human breast cancers in nude mice completely, without any apparent side effects. " 05/01/2009 - "GnRH-II has been shown to exert a strong antiproliferative action on tumors of the female reproductive system. " 10/01/2005 - "GnRH-II receptor-like antigenicity in human placenta and in cancers of the human reproductive organs."
2.	Endometriosis 11/01/2005 - "In the present study, we studied the possible implication of GnRH II in endometriosis. " 01/01/2013 - "GnRHII can significantly induce apoptosis in ectopic, eutopic and normal endometrial stromal cells from patients with endometriosis, especially to the ectopic." 01/01/2013 - "In vitro apoptosis effects of GnRHII on endometrial stromal cells from patients with endometriosis." 01/01/2013 - "GnRH-II significantly inhibited the cell proliferation, induced cell apoptosis and decreased the VEGF secreting of ectopic, eutopic and normal ESC in EMs in vitro, and these effects were the strongest on ectopic ESC, which suggested that GnRH-II may become a new effective treatment for endometriosis." 01/01/2013 - "To study the effect of GnRH-II on the cell proliferation, apoptosis and secreting vascular endothelial growth factor (VEGF) of ectopic, eutopic and normal endometrial stromal cells (ESC) from patients with or without endometriosis (EMs) in vitro. "
3.	Prostatic Neoplasms (Prostate Cancer) 02/01/2009 - "GnRH-II antagonists may hold promise in the treatment of prostate cancer." 05/01/2009 - "GnRH-II exerted an antiproliferative activity on prostate cancer cells. " 05/01/2009 - "We investigated the effects of GnRH-II on prostate cancer cell proliferation. " 05/01/2009 - "The data so far reported on the effects of GnRH-II on prostate cancer growth are controversial. " 02/01/2009 - "However, the role of GnRH-II in prostate cancer is unclear. "
4.	Ovarian Neoplasms (Ovarian Cancer) 03/01/2011 - "GnRH-II is produced by ovarian cancer cells and enhances their invasiveness in vitro. " 02/01/2011 - "GnRH-II enhances ovarian cancer cell invasion in an autocrine manner. " 03/01/2010 - "We have shown increased GnRH-II expression in human ovarian cancer tissue in post-menopausal women in vivo. " 02/15/2007 - "GnRH-II antagonists inhibited the growth of xenotransplants of human endometrial and ovarian cancers in nude mice significantly, without any apparent side effects. " 02/15/2007 - "Thus, GnRH-II antagonists seem to be suitable drugs for an efficacious and less toxic endocrine therapy for endometrial and ovarian cancers."
5.	Endometrial Neoplasms (Endometrial Cancer) 05/15/2009 - "However, more studies are necessary to elucidate the underlying molecular mechanisms and develop potential applications of GnRH-II. Therefore, we explored the mechanisms of GnRH-II-induced apoptosis and the effects of GnRH-II on GADD45alpha activation in human endometrial cancer cell lines. " 06/20/2013 - "Our findings represent a new concept regarding the mechanism of GnRH-II-induced cell motility in endometrial cancer cells and suggest the possibility of exploring GnRH-II as a potential therapeutic target for the treatment of human endometrial cancer." 05/15/2009 - "This finding may provide a new concept relating to the mechanism of GnRH-II-induced antiproliferation and apoptosis in endometrial cancer cells, indicating the possibility of GnRH-II as a promising therapeutic intervention for human endometrial cancer." 06/20/2013 - "Here, we examined the effect of a GnRH-II agonist on the motility of endometrial cancer cells and its mechanism of action in endometrial cancer therapy. " 06/20/2013 - "Our study indicates that GnRH-II agonist promoted cell motility of endometrial cancer cells through the GnRH-I receptor via the phosphorylation of ERK1/2 and JNK, and the subsequent, MAPK-dependent activation of MMP-2. "

Related Drugs and Biologics

1.	Gonadotropin-Releasing Hormone (GnRH)
2.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
3.	LHRH Receptors (Gonadotropin-Releasing Hormone Receptor)
4.	Messenger RNA (mRNA)
5.	p38 Mitogen-Activated Protein Kinases
6.	Protein Kinases (Protein Kinase)
7.	Triptorelin Pamoate (Trelstar)
8.	Gonadotropins
9.	Mitogen-Activated Protein Kinases
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Vascular Access Devices (Arterial Line)
4.	Injections
5.	Aftercare (After-Treatment)