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esperamicin A1
from Actinomadura verrucosospora; RN refers to (1S,(1R*,4Z,8S*,12S*,13E))-isomer
Also Known As:
BBM 1675A; BBM-1675A; BMY 28175; BMY-28175; esperamicin
Networked:
2
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Carbohydrates: 22023
Glycosides: 2119
Aminoglycosides: 5131
esperamicin A1: 2
Organic Chemicals: 133
Hydrocarbons: 1713
Acyclic Hydrocarbons
Alkenes: 265
Enediynes: 19
esperamicin A1: 2
Alkynes: 217
Polyynes: 10
Diynes: 3
Enediynes: 19
esperamicin A1: 2
Related Diseases
1.
Neoplasms (Cancer)
02/01/1990 - "
BMY-28175 was evaluated for antitumor activity against several experimental murine and human tumor models.
"
02/01/1990 - "
BMY-28175 was active against sc implanted B16 melanoma (increased lifespan and/or inhibition of primary tumor growth) in about 60% of the tests.
"
02/01/1990 - "
The results of these studies indicate that BMY-28175 is one of the most potent antitumor agents yet observed, with a broad spectrum of activity against tumors of murine and human origin and activity against tumors located distal to the site of drug administration.
"
2.
Experimental Melanoma
02/01/1990 - "
BMY-28175 was active against sc implanted B16 melanoma (increased lifespan and/or inhibition of primary tumor growth) in about 60% of the tests.
"
3.
Leukemia
02/01/1990 - "
In addition, BMY-28175 administered iv was active against iv implanted P388 and L1210 leukemias.
"
4.
Dehydration (Water Stress)
05/04/1993 - "
The results reported here provide several important insights: (1) esperamicin A1 requires a purine/pyrimidine trimer in host DNA for favorable interaction, (2) the sequence selectivity of esperamicin C is an origin of esperamicin A1 and calicheamicin gamma 1I selectivities, (3) in the target recognition by esperamicin C, its total structure and hydrophobicity are important, and (4) the binding of hydrophobic esperamicin to DNA duplex induces dehydration and conformational change of the host DNA.
"
Related Drugs and Biologics
1.
Antineoplastic Agents (Antineoplastics)
2.
esperamicin A1
3.
DNA (Deoxyribonucleic Acid)
4.
Calicheamicins
5.
esperamicin C
6.
pyrimidine
7.
purine