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N- acetylmuramyl- alanyl- isoglutamine- alanyl- cholesterol
Also Known As:
3-O-(MDP-Ala)cholesterol; MDP-alanyl-cholesterol; MTP-CHOL; MTP-alanyl-3-O-cholesterol
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Carbohydrates: 22023
Amino Sugars: 110
Muramic Acids: 28
Acetylmuramyl-Alanyl-Isoglutamine: 467
N-acetylmuramyl-alanyl-isoglutamine-alanyl-cholesterol: 4
Sugar Acids: 4
Muramic Acids: 28
Acetylmuramyl-Alanyl-Isoglutamine: 467
N-acetylmuramyl-alanyl-isoglutamine-alanyl-cholesterol: 4
Amino Acids, Peptides, and Proteins: 1
Peptides: 82426
Glycopeptides: 1928
Acetylmuramyl-Alanyl-Isoglutamine: 467
N-acetylmuramyl-alanyl-isoglutamine-alanyl-cholesterol: 4
Polycyclic Compounds: 6
Fused-Ring Compounds
Steroids: 70059
Cholestanes
Sterols: 2245
Cholesterol: 67133
Cholesterol Esters: 1623
N-acetylmuramyl-alanyl-isoglutamine-alanyl-cholesterol: 4
Cholestenes
Cholesterol: 67133
Cholesterol Esters: 1623
N-acetylmuramyl-alanyl-isoglutamine-alanyl-cholesterol: 4
Lipids: 114793
Membrane Lipids: 1591
Sterols: 2245
Cholesterol: 67133
Cholesterol Esters: 1623
N-acetylmuramyl-alanyl-isoglutamine-alanyl-cholesterol: 4
Related Diseases
1.
Neoplasms (Cancer)
12/30/1994 - "
Treatment with muramyldipeptide (MDP) or a lipophilic derivative (MTP-Chol) included in nanocapsules renders macrophages cytostatic towards tumor cells.
"
10/01/1985 - "
The ability of liposomes containing a new lipophilic muramyl peptide derivative, MDP-L-alanyl-cholesterol (MTP-CHOL), to induce peritoneal macrophage cytostatic activity and alveolar macrophage cytotoxic activity toward tumor cell targets in vitro was determined.
"
2.
Neoplasm Metastasis (Metastasis)
01/01/1991 - "
The dose of MTP-Chol in each injection, and the tumour burden in the mice did not change the percentage inhibition of metastases significantly.
"
05/01/1994 - "
A lipophilic immunomodulator (MTP-Chol) was included in nanocapsules prepared from different polymers and the anti-metastatic effects of the resulting drug delivery systems were evaluated in a murine model of liver metastases.
"
01/01/1991 - "
A lipophilic muramylpeptide (MTP-Chol), capable of rendering macrophages cytostatic towards tumour cells, was encapsulated within polyisobutylcyanoacrylate nanocapsules and administered to mice carrying an experimental model of liver metastasis.
"
Related Drugs and Biologics
1.
Cytostatic Agents
2.
Nanocapsules
3.
Polymers
4.
Peptides (Polypeptides)
5.
Liposomes (Liposome)
6.
Immunologic Factors (Immunomodulators)
7.
Enbucrilate
8.
Cholesterol