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bis(beta-carbobutoxyethyl)tin dichloride

Also Known As:

CBETC

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Organometallic Compounds: 64
  - Organotin Compounds: 41
    - bis(beta-carbobutoxyethyl)tin dichloride: 2

Related Diseases

1.	Atrophy 12/01/1982 - "Since the dicarboxyltin compound CETC induced no signs of lymphocytotoxicity in the in vitro cell-metabolism, cell-viability or blast-transformation studies, hydrolysis of CBETC and CMETC to CETC in the rat is suggested as a possible explanation for the discrepancy between the lymphocytotoxic activity of the estertin compounds in vitro and the absence of lymphoid atrophy following in vivo exposure, and for the finding that in the rat CMETC and CBETC are much less toxic than the dialkyltin compounds DBTC and DOTC, which induce lymphocytotoxicity both in vitro and in vivo." 12/01/1982 - "Parenteral exposure demonstrated a similar difference in toxicity between these groups; a single ip or iv injection of 2.5 mg DBTC/kg body weight caused a slight reduction in body-weight gain and severe thymic atrophy, whereas CBETC and CETC had no such effects even at 10 mg/kg. However, in vitro the activities of the esterins were similar to those of the dialkyltins. "
2.	Body Weight (Weight, Body) 12/01/1985 - "Daily gavage of 15 mg CBETC/kg body weight resulted in the excretion of appreciable amounts of CETC in urine, but CETC was also found in faeces together with the parent compound. " 12/01/1985 - "After daily intravenous administration of 20 mg CBETC/kg body weight CETC was detected in urine only, whereas no faecal excretion of organotin was found. " 12/01/1982 - "Parenteral exposure demonstrated a similar difference in toxicity between these groups; a single ip or iv injection of 2.5 mg DBTC/kg body weight caused a slight reduction in body-weight gain and severe thymic atrophy, whereas CBETC and CETC had no such effects even at 10 mg/kg. However, in vitro the activities of the esterins were similar to those of the dialkyltins. "

Related Drugs and Biologics

1.	bis(beta-carboxyethyl)tin dichloride
2.	2'-deoxy-3'-oxa-thiocytidine (DOTC)
3.	Dihydrotachysterol (AT 10)

Related Therapies and Procedures

1.	Intravenous Administration