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bis(3,5- dimethyl- 5- hydroxymethyl- 2- oxomorpholin- 3- yl)

radical dimer which reacts with adriamyin to produce aglycone; structure given in first source

Also Known As:

DHM3

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Oxazines: 9
    - Morpholines: 6
      - bis(3,5-dimethyl-5-hydroxymethyl-2-oxomorpholin-3-yl): 2

Related Diseases

1.	Necrosis 01/01/1986 - "Furthermore, DHM3 is an effective antidote for DOX-induced skin necrosis and has potential for clinical use." 01/01/1988 - "Hydrocortisone sodium succinate was not effective for the treatment of doxorubicin-induced skin necrosis, whereas DHM3 was effective for the treatment of skin necrosis caused by all seven anthracyclines and by the quinone containing antibiotic, mitomycin C."
2.	Ulcer 01/01/1986 - "When DHM3 was administered into the same intradermal injection site 15 minutes after DOX, the maximum ulcer size was reduced 80%, and the healing time was reduced to 5 weeks. "

Related Drugs and Biologics

1.	Succinic Acid (Succinate)
2.	Anthracyclines
3.	Mitomycin (Mitomycin-C)
4.	Sodium
5.	Hydrocortisone (Cortisol)
6.	Doxorubicin (Adriamycin)
7.	Anti-Bacterial Agents (Antibiotics)
8.	quinone (benzoquinone)
9.	Antidotes

Related Therapies and Procedures

1.	Intradermal Injections