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7-chloro-4-aminoquinoline

structure given in first source

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Aminoquinolines: 29
        7-chloro-4-aminoquinoline: 4

Experts

1.	França, Tanos C C: 2 articles (10/2021 - 01/2019)
2.	Lima, Flavia R S: 2 articles (10/2021 - 01/2019)
3.	Lima, Josélia A: 2 articles (10/2021 - 01/2019)
4.	Vargas, Maria D: 2 articles (10/2021 - 01/2019)
5.	Zanon, Vanessa S: 2 articles (10/2021 - 01/2019)
6.	Amaral, Rackele F: 1 article (10/2021)
7.	Kitagawa, Daniel A S: 1 article (10/2021)
8.	Cuya, Teobaldo: 1 article (01/2019)
9.	Gomez, Javier G: 1 article (01/2019)
10.	Ribeiro, Ronny R: 1 article (01/2019)

Related Diseases

1.	Malaria 01/01/2017 - "Synthesis and Evaluation of Chirally Defined Side Chain Variants of 7-Chloro-4-Aminoquinoline To Overcome Drug Resistance in Malaria Chemotherapy." 10/01/2009 - "Two new quinolizidinyl-alkyl derivatives of 7-chloro-4-aminoquinoline, named AM-1 and AP4b, which are highly effective in vitro against both the D10 (chloroquine [CQ] susceptible) and W2 (CQ resistant) strains of Plasmodium falciparum and in vivo in the rodent malaria model, have been studied for their ability to bind to and be internalized by normal or parasitized human red blood cells (RBC) and for their effects on RBC membrane stability. "
2.	Alzheimer Disease (Alzheimer's Disease) 10/01/2021 - "In search of a novel class of compounds against Alzheimer's disease (AD), a new series of 7-chloro-aminoquinoline derivatives containing methylene spacers of different sizes between the 7-chloro-4-aminoquinoline nucleus and imino methyl substituted phenolic rings, and also their reduced analogues, were designed, synthesized and evaluated as neuroprotective agents for AD in vitro. " 01/01/2019 - "Hence, a series of 7-chloro-4-aminoquinoline Schiff bases (HLa-e) were synthesized and their cytotoxicity and anti-cholinesterase activity, assessed for Alzheimer's disease. "

Related Drugs and Biologics

1.	Chloroquine (Aralen)
2.	Neuroprotective Agents
3.	Schiff Bases (Schiff Base)
4.	Cholinesterase Inhibitors (Anticholinesterases)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)