NSC 350386
structure given in first source; NSC 370147 is the 2-hydroxyethanesulfonate hydrate, also called isethionate hydrate; NSC 613862 is the (S(-))-enantiomer; NSC 613863 is the (R(+))-enantiomer; RN given refers to compound with no isomeric designation
Also Known As:
NSC 350386, (S)-isomer; NSC 370147; NSC 613862; NSC 613863; NSC-350386; NSC-370147; NSC-613862; NSC-613863; ethyl 5-amino-1,2-dihydro-2-methyl-3-phenylpyrido(3,4-b)pyrazin-7-carbamate
Networked: 5
relevant articles (0 outcomes,
1 trials/studies)
Bio-Agent Context: Research Results
Related Diseases
1. | Colorectal Neoplasms (Colorectal Cancer)
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2. | Neoplasms (Cancer)
06/01/1990
- " Ethyl 5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazin- 7-ylcarbamate, 2-hydroxyethanesulfonate, hydrate (NSC 370147) was evaluated for antitumor activity against a spectrum of tumor systems in culture and in mice. " 06/01/1990
- " Antitumor activity of ethyl 5-amino-1,2-dihydro-2-methyl-3-phenyl-pyrido [3,4-b]pyrazin-7-ylcarbamate, 2-hydroxyethanesulfonate, hydrate (NSC 370147) against selected tumor systems in culture and in mice." 01/01/1992
- " This information plus other in vivo cross-resistance data [Waud et al. (1990) Cancer Res 50: 3239] suggests that NSC 370147 may be useful in non-cross-resistant combinations with doxorubicin, melphalan, cisplatin, or methotrexate. "
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3. | Leukemia
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4. | Experimental Neoplasms
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5. | Leukemia P388
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