NSC 350386

structure given in first source; NSC 370147 is the 2-hydroxyethanesulfonate hydrate, also called isethionate hydrate; NSC 613862 is the (S(-))-enantiomer; NSC 613863 is the (R(+))-enantiomer; RN given refers to compound with no isomeric designation

Also Known As:

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 12/01/1997 - "Phase II trial of intravenous CI-980 (NSC 370147) in patients with metastatic colorectal carcinoma. "
2.	Neoplasms (Cancer) 06/01/1990 - "Ethyl 5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazin- 7-ylcarbamate, 2-hydroxyethanesulfonate, hydrate (NSC 370147) was evaluated for antitumor activity against a spectrum of tumor systems in culture and in mice. " 06/01/1990 - "Antitumor activity of ethyl 5-amino-1,2-dihydro-2-methyl-3-phenyl-pyrido [3,4-b]pyrazin-7-ylcarbamate, 2-hydroxyethanesulfonate, hydrate (NSC 370147) against selected tumor systems in culture and in mice." 01/01/1992 - "This information plus other in vivo cross-resistance data [Waud et al. (1990) Cancer Res 50: 3239] suggests that NSC 370147 may be useful in non-cross-resistant combinations with doxorubicin, melphalan, cisplatin, or methotrexate. "
3.	Leukemia 01/01/1994 - "We have characterized the inhibition of in vitro microtubule assembly by the S (CI 980) and R (NSC 613863) enantiomers, their actions on the cytoplasmic microtubule network of epithelial-like PtK2 cells, and on the cell cycle of different human and murine leukemias and PtK2 cells. " 06/01/1990 - "NSC 370147 was as active against murine leukemia sublines resistant to Adriamycin, amsacrine, vincristine, melphalan, cisplatin, methotrexate, and CI-920 (a topoisomerase II inhibitor) as against the corresponding parental lines. "
4.	Experimental Neoplasms 03/15/1987 - "It is suggested that it would be worthwhile to evaluate combinations of NSC 370147 and vincristine in tests with other experimental neoplasms."
5.	Leukemia P388 01/01/1992 - "A P388 leukemia resistant to NSC 370147 (P388/NSC 370147) was isolated and its in vivo cross-resistance profile was determined. "

Related Drugs and Biologics

1.	canertinib dihydrochloride
2.	Vincristine (Oncovin)
3.	Methotrexate (Mexate)
4.	Melphalan (Alkeran)
5.	Doxorubicin (Adriamycin)
6.	Cisplatin (Platino)
7.	Topoisomerase II Inhibitors
8.	Amsacrine (AMSA)
9.	fostriecin