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phenylamil

irreversible inhibitor of sodium channels in the toad urinary bladder

Also Known As:

phenamil

Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrazines: 150
    - Amiloride: 1400
      - phenylamil: 9

Experts

1.	Leyva-Jimenez, Hector: 1 article (07/2017)
2.	Moncada, Kristin: 1 article (07/2017)
3.	Park, Kye Won: 1 article (07/2017)
4.	Price, Tara R: 1 article (07/2017)
5.	Tontonoz, Peter: 1 article (07/2017)
6.	Walzem, Rosemary L: 1 article (07/2017)
7.	Aghaloo, Tara L: 1 article (01/2017)
8.	Cui, Zhong-Kai: 1 article (01/2017)
9.	Fan, Jiabing: 1 article (01/2017)
10.	Guo, Mian: 1 article (01/2017)

Related Diseases

1.	Vascular Remodeling 02/01/2011 - "Here, we demonstrate that infusion of the amiloride analog phenamil during chronic-hypoxia treatment in rat attenuates development of PAH and vascular remodeling. " 02/01/2011 - "The amiloride derivative phenamil attenuates pulmonary vascular remodeling by activating NFAT and the bone morphogenetic protein signaling pathway."
2.	Wounds and Injuries (Trauma) 06/01/2005 - "We have determined that the replacement of extracellular Na(+) by choline and the incorporation of phenamil, an inhibitor of the epithelial Na(+) channel (ENaC), provoke a decrease in the actin cable and depolarization areas and in the lamellar activity of the wound edges. "
3.	Tuberculosis (Tuberculoses) 01/01/2023 - "CMap was used to predict potential therapeutic compounds for tuberculosis using 300 differentially expressed genes (150 downregulated and 150 upregulated genes), and six small molecules (RWJ-21757, phenamil, benzanthrone, TG-101348, metyrapone, and WT-161) with a higher confidence value were extracted. "
4.	Osteomyelitis 08/01/2022 - "Herein, a pH-sensitive silk fibroin (SF)/sodium alginate (SA) hydrogel scaffolds containing teicoplanin (TEC) and phenamil (PM) loaded SF nanoparticles (PMSFNPS) are introduced for treating chronic osteomyelitis. "
5.	Infections 08/01/2022 - "Dual drug delivery system of teicoplanin and phenamil based on pH-sensitive silk fibroin/sodium alginate hydrogel scaffold for treating chronic bone infection."

Related Drugs and Biologics

1.	Hydrogels
2.	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)
3.	Teicoplanin
4.	Sodium
5.	Metyrapone
6.	Fibroins (Fibroin)
7.	Choline (Choline Chloride)
8.	Calcium
9.	Amiloride (Midamor)
10.	Alginates

Related Therapies and Procedures

1.	Oral Administration