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1'-hydroxy-2',3'-dehydroestragole

synthetic acetylenic analog of estragole; structure given in first source

Also Known As:

OHDHE

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Phenyl Ethers: 8
        Anisoles
        1'-hydroxy-2',3'-dehydroestragole: 3
- Ethers: 242
  - Methyl Ethers: 19
    - Anisoles
      - 1'-hydroxy-2',3'-dehydroestragole: 3
  - Phenyl Ethers: 8
    - Anisoles
      - 1'-hydroxy-2',3'-dehydroestragole: 3

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 05/01/1987 - "The acetylenic compounds 1'-hydroxy-2',3'-dehydroestragole and 1'-hydroxy-2',3'-dehydrosafrole were the most potent derivatives studied; they were 5- and 10-fold more potent (based on the average numbers of hepatomas per liver) than the corresponding allylic benzene derivatives. " 08/01/1986 - "DNA from each of 25 hepatomas, induced by N-hydroxy-2-acetylaminofluorene, vinyl carbamate, or 1'-hydroxy-2',3'-dehydroestragole, containing transforming activity in the NIH 3T3 transfection assay. " 11/01/1985 - "The administration of pentachlorophenol (0.04 mumol/g body weight) 45 min prior to a single dose of 1'-hydroxy-2',3'-dehydroestragole (0.04 mumol/g body weight) in 12-day-old male B6C3F1 mice greatly inhibited (87-97%) the covalent binding of 1'-hydroxy-2',3'-dehydroestragole to hepatic macromolecules and the formation of hepatomas at 10 months.(ABSTRACT TRUNCATED AT 400 WORDS)"
2.	Body Weight (Weight, Body) 11/01/1985 - "The administration of pentachlorophenol (0.04 mumol/g body weight) 45 min prior to a single dose of 1'-hydroxy-2',3'-dehydroestragole (0.04 mumol/g body weight) in 12-day-old male B6C3F1 mice greatly inhibited (87-97%) the covalent binding of 1'-hydroxy-2',3'-dehydroestragole to hepatic macromolecules and the formation of hepatomas at 10 months.(ABSTRACT TRUNCATED AT 400 WORDS)"

Related Drugs and Biologics

1.	Pentachlorophenol (Sodium Pentachlorophenate)
2.	DNA (Deoxyribonucleic Acid)
3.	Dihydrotachysterol (AT 10)
4.	Benzene Derivatives
5.	Alkynes (Acetylenes)
6.	vinyl carbamate