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AR 12456

3',5'-cyclic nucleotide phosphodiesterase inhibitor

Also Known As:

AR-12-456

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Triazoles: 1533
      - Trapidil: 134
        AR 12456: 5
  - Pyrimidines: 510
    - Trapidil: 134
      - AR 12456: 5

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 01/01/1993 - "Effect of trapidil derivative AR 12456 on intracellular cholesterol homeostasis in human hepatoma cell line Hep G2." 01/01/1993 - "Effect of trapidil derivative AR 12456 on intracellular cholesterol homeostasis in human hepatoma cell line Hep G2." 10/01/1991 - "The effect of trapidil (Rocornal) and its derivatives AR 12456 and AR 12463 on endogenous cholesterol synthesis and on cholesterol esterification rate was studied in human skin fibroblasts (HSF), in human hepatoma cell line Hep G2 and in primary culture of peritoneal macrophages from mouse (PMM). " 09/01/1989 - "The effect of trapidil (RocornalR) and some of its newly developed derivatives (AR 12456, AR 12463, AR 12465, AR 12464) on the receptor-mediated low density lipoprotein (LDL) binding, uptake and degradation was studied in human skin fibroblasts (HSF) and in human hepatoma cell line Hep G2. "
2.	Hyperlipidemias (Hyperlipidemia) 03/01/1991 - "The trapidil derivative AR 12456 protects against serum hyperlipidemia in guinea pigs."

Related Drugs and Biologics

1.	Trapidil
2.	Cholesterol
3.	AR 12463
4.	LDL Lipoproteins (beta Lipoproteins)
5.	oxidized low density lipoprotein
6.	AR 12465