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1,2,3,4,6,7,8-heptachlorodibenzodioxin

contaminant of pentachlorophenol
Also Known As:
1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin; HCDD; HpCDD
Networked: 24 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Sato, Hiroshi: 2 articles (12/2013 - 01/2010)
2. Soma, Jun: 2 articles (12/2013 - 01/2010)
3. Oe, Yuji: 2 articles (12/2013 - 01/2010)
4. Wang, Long: 1 article (01/2015)
5. Chen, Qianxue: 1 article (01/2015)
6. Marupudi, Sindhuja: 1 article (01/2015)
7. Liu, Baohui: 1 article (01/2015)
8. Zhang, Li: 1 article (01/2015)
9. Kuppusamy, Tamil: 1 article (01/2015)
10. Liu, Zaiming: 1 article (01/2015)

Related Diseases

1. Nephrotic Syndrome (Syndrome, Nephrotic)
2. Body Weight (Weight, Body)
3. Renal Insufficiency (Renal Failure)
4. Paraproteinemias (Monoclonal Gammopathy)
5. Neoplasms (Cancer)
03/01/1994 - "It is concluded that (i) different PCDD level-response relationships exist for the induction of hepatic CYP1A activity and the promotion of preneoplastic liver foci, and (ii) that TE or ITE factors provide only a rough estimate of the tumor-promoting potency of a PCDD mixture but may overestimate the risk from exposure to higher-chlorinated 2,3,7,8-substituted congeners such as HpCDD."
10/01/1987 - "1,2,3,6,7,8- and 1,2,3,7,8,9-hexachlorodibenzo-p-dioxin (HCDD) (1-1000 nM) and 2,7-dichlorodibenzo-p-dioxin (0.1-20 microM) failed to transform C3H/10T1/2 cells or to initiate transformation in cultures subsequently treated with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate. "
01/01/2010 - "The protein expressions of IL-8 and its receptors in tumor xenografts and gastric tissue adjacent to the tumor were markedly higher than those in the gastric tissue in normal mice (P<0.01); compared with HCDD and FT-207, XTSJD could significantly decrease the IL-8 protein expression in tumor xenografts and gastric tissue adjacent to the tumor (P<0.05); compared with FT-207, XTSJD could significantly decrease the CXCR1 protein expression in tumor xenografts (P<0.01), and XTSJD could also significantly decrease the CXCR1 protein expression in gastric tissue adjacent to the tumor as compared with HCDD and FT-207 (P<0.01); compared with HCDD and FT-207, XTSJD could significantly decrease the CXCR2 protein expression in tumor xenografts (P<0.01), and there was no significant difference among the three drug-treated groups in CXCR2 protein expression in gastric tissue adjacent to the tumor (P>0.05). "
03/01/1994 - "In a two-stage initiation-promotion experiment the hypothesis was investigated that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) equivalents (TE), calculated from data of CYP1A induction in hepatocytes in primary culture, or international TCDD equivalents (ITE) are useful for evaluating the tumor-promoting potency of 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin (HpCDD) and of a defined mixture (M2) of 49 polychlorinated dibenzo-p-dioxins (PCDDs) in comparison with TCDD. "

Related Drugs and Biologics

1. Proteasome Endopeptidase Complex (Proteasome)
2. bortezomib (Velcade)
3. Tetrachlorodibenzodioxin (TCDD)
4. 1,2,3,7,8-pentachlorodibenzo-p-dioxin
5. 1,2,3,6,7,8-hexachlorodibenzodioxin
6. Immunoglobulins (Immunoglobulin)
7. Immunoglobulin G (IgG)
8. 1,2,3,4,6,7,8-heptachlorodibenzodioxin
9. Interleukin-8B Receptors
10. Polyethylene (Polythene)

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)
2. Activities of Daily Living (ADL)