HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

amflutizole

xanthine oxidase inhibitor; structure given in first source

Also Known As:

4-amino-3-(3-(trifluoromethyl)phenyl)-5-isothiazole carboxylic acid

Networked: 4 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - amflutizole: 4
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - amflutizole: 4

Related Diseases

1.	Ischemia 10/01/1994 - "Amflutizole also eliminated the ischemia/reperfusion-evoked generation of free radical adducts of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone (POBN) detected by electron spin resonance. " 10/01/1994 - "These results are consistent with a block of xanthine oxidase by amflutizole and support the involvement of xanthine oxidase in free radical mediated tissue damage following ischemia/reperfusion." 10/01/1994 - "Amflutizole, 10 microM administered topically into the cortical cups, enhanced the ischemia-evoked release of hypoxanthine while it suppressed xanthine formation. " 10/01/1994 - "The effect of amflutizole, a xanthine oxidase inhibitor, on ischemia-evoked purine release and free radical formation in the rat cerebral cortex."
2.	Hyperuricemia 06/01/1985 - "The antihyperuricemic properties of amflutizole were investigated in studies designed to determine its efficacy and mechanisms of action in individuals with gout and hyperuricemia. "
3.	Gout 06/01/1985 - "Antihyperuricemic properties of amflutizole in gout." 06/01/1985 - "The antihyperuricemic properties of amflutizole were investigated in studies designed to determine its efficacy and mechanisms of action in individuals with gout and hyperuricemia. "
4.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 09/01/1996 - "The antioxidant actions of dimethyl sulphoxide, ascorbate, and the novel compounds, amflutizole and LY231617 in this model suggest that these agents merit further assessment in the treatment of inflammatory bowel disease."
5.	Infarction (Infarctions) 03/01/1991 - "Infarct size for the amflutizole-treated dogs, 40 +/- 21%, was not significantly different from that of the control group. "

Related Drugs and Biologics

1.	Free Radicals
2.	alpha- (4- pyridyl- 1- oxide)- N- tert- butylnitrone
3.	Gout Suppressants (Antigout Agents)
4.	Xanthine
5.	Hypoxanthine
6.	Xanthine Oxidase
7.	Dimethyl Sulfoxide (DMSO)
8.	Antioxidants
9.	LY 231617
10.	purine