triperiden

01/01/1992 - "Relation between drug resistance and antigenicity among norakin-resistant mutants of influenza A (fowl plague) virus."
01/01/1985 - "In cell culture, primary transcription of influenza A/FPV/Weybridge and of influenza B/Japan/73 is strongly inhibited by Norakin (20 micrograms/ml). "
01/01/1985 - "The influence of Norakin on the reproduction of influenza A and B viruses."
01/01/1988 - "The nucleotide sequences of the hemagglutinin genes of four norakin-resistant mutants of Influenza A/FPV/Weybridge were determined and compared to the wild-type hemagglutinin. "
01/01/1985 - "Rimantadine-resistant mutants of influenza A exhibit a definite, though limited, cross-resistance to Norakin, and vice versa. "

03/01/1989 - "The development of lung lesions in RSV-infected BALB/c mice was suppressed by 70% when the animals were treated with two doses (25 mg/kg each) of norakin, 30 min before and 4 hr post infection. "
05/01/1985 - "Administration of Norakin up to doses of 300 mg/kg body mass per day to noninfected ABD2F1 mice were tolerated without obvious clinical or histological signs of illness over a period of 104 hr. Replication of sindbis virus in BHK 21/C13 cells was not inhibited by Norakin concentrations up to 10 micrograms/ml. In Mengo virus-infected mice Norakin did not exert any protective effect within the range of 1.25-50.0 mg/kg body mass when treatment started 1 hr before infection and has been continued twice daily over a period of 104 hr."

06/01/1986 - "The anticholinergic anti-parkinsonism drug Norakin is an inhibitor of influenza virus multiplication. "

05/01/1985 - "Inhibition by Norakin (triperiden) of Sindbis virus infection in mice."

05/01/1994 - "We therefore suggest that norakin does not interact directly with the viral hemagglutinin, but inhibits viral infection through increase of the internal pH in the prelysosomal compartment."