mosapramine

structure given in first source

Also Known As:

3-chloro-5-(3-(2-oxo-1,2,3,5,6,7,8,8a-octahydroimidazo(1,2-a)pyridine-3-spiro-4'-piperidino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine; Y 516; Y-516; Spiro(imidazo(1,2-a)pyridine-3(2H),4'-piperidin)-2-one, 1'-(3-(3-chloro-10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl)hexahydro-, dihydrochloride

Networked: 6 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzazepines: 5
      - mosapramine: 6

Experts

1.	Iwata, Nakao: 3 articles (01/2014 - 09/2013)
2.	Kishi, Taro: 3 articles (01/2014 - 09/2013)
3.	Matsuda, Yuki: 2 articles (01/2014 - 01/2014)
4.	Matsunaga, Shinji: 1 article (01/2014)
5.	Fujimura, M: 1 article (10/2000)
6.	Hashimoto, K: 1 article (10/2000)
7.	Yamagami, K: 1 article (10/2000)

Related Diseases

1.	Hyperprolactinemia 01/01/2014 - "However, mosapramine was associated with a greater risk of extrapyramidal symptoms and hyperprolactinemia than the other SGAs were, although it may be beneficial for the improvement of positive symptoms." 01/01/2014 - "Furthermore, the incidences of extrapyramidal symptoms and of hyperprolactinemia were significantly greater with mosapramine than with the other pooled antipsychotics. "
2.	Schizophrenia (Dementia Praecox) 01/01/1999 - "Although both additions resulted in significant, albeit modest, improvement, there was no significant difference in the scores on the Positive and Negative Syndrome Scale for Schizophrenia between risperidone and mosapramine addition. " 10/27/2000 - "These results suggest that the ability of mosapramine to enhance expression of Fos protein in the medial prefrontal cortex may contribute to a clozapine-like profile with respect to actions on negative symptoms in schizophrenia. " 01/01/1999 - "Comparison of risperidone and mosapramine addition to neuroleptic treatment in chronic schizophrenia." 01/01/2014 - "We conducted a meta-analysis of the iminodibenzyl antipsychotics carpipramine, clocapramine, and mosapramine, which are classified as second-generation antipsychotics (SGAs) for schizophrenia treatment. " 01/01/2014 - "Iminodibenzyl class antipsychotics for schizophrenia: a systematic review and meta-analysis of carpipramine, clocapramine, and mosapramine."
3.	Vomiting 09/01/1985 - "Y-516 inhibited apomorphine (0.5 mg/kg, s.c.)-induced hyperactivity in mice, apomorphine (10 mg/kg, s.c.)-induced hypothermia in mice, apomorphine (0.1 mg/kg, s.c.)-induced vomiting in dogs, methamphetamine (2 mg/kg, s.c.)-induced hyperactivity in mice and methamphetamine (50 mg/kg, i.p.)-induced mortality in grouped mice. "

Related Drugs and Biologics

1.	Antipsychotic Agents (Antipsychotics)
2.	Risperidone (Risperdal Consta)
3.	Haloperidol (Haldol)
4.	Olanzapine (Zyprexa)
5.	Quetiapine Fumarate (Seroquel)
6.	Aripiprazole (Abilify)
7.	perospirone
8.	Proteins (Proteins, Gene)
9.	Methamphetamine (Desoxyn)
10.	Clozapine (Clozaril)

Related Therapies and Procedures

1.	Induced Hypothermia