angiogenin

human tumor protein which stimulates growth of blood vessels; contains 123 amino acids; member of the pancreatic ribonuclease superfamily; MW 14,400

Also Known As:

ANG protein, human; Ang protein, rat; RNase-5; ang protein, mouse; angiogenin protein, mouse; angiogenin protein, rat; angiogenin, ribonuclease, RNase A family, 5 protein, rat; angiogenin, ribonuclease, RNase A family, 5, human; angiogenin-1; ribonuclease 5

Networked: 556 relevant articles (15 outcomes, 87 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Esterases: 1574
      - Ribonucleases: 2046
        Endoribonucleases: 176
        Pancreatic Ribonuclease: 250
        angiogenin: 556
      - Endonucleases: 1227
        Endoribonucleases: 176
        Pancreatic Ribonuclease: 250
        angiogenin: 556

Experts

1.	Hu, Guo-Fu: 18 articles (01/2022 - 01/2005)
2.	Xu, Zhengping: 13 articles (03/2022 - 04/2005)
3.	Sheng, Jinghao: 9 articles (03/2022 - 10/2013)
4.	Gomes, James: 9 articles (01/2021 - 01/2012)
5.	Padhi, Aditya K: 9 articles (01/2021 - 01/2012)
6.	Hu, Guo-fu: 9 articles (05/2014 - 06/2002)
7.	Lip, Gregory Y H: 9 articles (08/2013 - 12/2007)
8.	Ibaragi, Soichiro: 8 articles (01/2022 - 03/2009)
9.	Li, Shuping: 8 articles (01/2022 - 03/2009)
10.	La Mendola, Diego: 7 articles (01/2022 - 03/2015)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2009 - "To study the inhibition of angiogenin (ANG) expression in human lung squamous cancer cell strain-A549 through adeno-associated virus (AAV)-mediated RNA-interference, and therefore to observe its effect on the growth of cancer cells and tumor formation. " 11/27/2007 - "These findings provide new clues for further studies on the mechanisms of angiogenin-induced angiogenesis or cancer cell growth." 12/15/2023 - "We identified 50 putative communication channels specifically used by cancer cells to interact with other cells, including two novel angiogenin-mediated interactions. " 01/01/2023 - "Angiogenin (ANG) has been widely reported as a crucial molecular regulator in multiple malignancies. " 01/01/2023 - "Human angiogenin (hAng), being a potent inducer of angiogenesis, is a cause of tumor cell proliferation, therefore its inhibition becomes a vital area of research. "
2.	Hypoxia (Hypoxemia) 05/01/2008 - "Angiogenin modified MSCs enhanced the tolerance of engrafted MSCs to hypoxia injury in vitro and improved their viability in infracted hearts, thus helping preserve the LV contractile function and attenuate LV remodeling through vasculogenesis." 12/01/2011 - "The aim of the present study was to ascertain the prognostic importance of hypoxia-inducible factors (CD105, angiogenin) and EGFR in a series of patients who underwent primary surgery followed by RT for laryngeal SCC. " 01/01/2019 - "Overall, these results suggest a link between hypoxia, HIF-1 signaling and angiogenin in the periodontium." 01/01/2018 - "Suppression of COUP-TFII by hypoxia stimulates angiogenesis through induction of angiogenin (ANG). " 11/02/2017 - "A significant decrease in angiogenin secretion levels and a significant increase in bFGF were observed following light exposure, compared to dark conditions, in both normoxia and hypoxia conditions. "
3.	Carcinoma (Carcinomatosis) 11/01/2013 - "To the best of our knowledge, this study was the first to investigate multiple angiogenic factors in the lysates of laryngeal carcinomas and metastatic nodes and identified angiogenin and IGFBP3 as factors possibly involved in tumour progression. " 09/01/2013 - "The role of angiogenin in pT1-T2 tongue carcinoma neo-angiogenesis and cell proliferation: an exploratory study." 07/01/2005 - "The results of this study demonstrated that the plasma levels of angiogenin were significantly higher in patients who had bladder carcinoma compared with healthy control participants and in patients with superficial bladder carcinoma who had recurrent disease compared with patients who were without recurrence. " 11/01/2016 - "Angiogenin elevates the invasive potential of squamous cell lung carcinoma cells through epithelial‑mesenchymal transition." 01/01/2013 - "Angiogenin expression (in carcinoma or endothelial cells) was not associated with prognosis. "
4.	Burns 01/01/2018 - "Previously, we found that angiogenin promoted neovascularization during deep burn wound healing. " 09/01/2012 - "Blocking the effect of angiogenin in burn blister fluids resulted in a significant reduction of endothelial cell proliferation, CAC differentiation, and new blood vessels formation in vivo. " 02/27/2020 - "In this study, we developed a paper-based ELISA (P-ELISA) technique for rapid assessment of angiogenin concentration in burn blister fluid. " 01/01/2018 - "In our previous study, we found that deep partial-thickness burn (DPTB) wounds showed higher expression levels of angiogenin to enhance vascularization compared with superficial partial-thickness burn wounds. " 02/27/2020 - "Preliminary Assessment of Burn Depth by Paper-Based ELISA for the Detection of Angiogenin in Burn Blister Fluid-A Proof of Concept."
5.	Disease Progression 03/01/2003 - "In conclusion, serum angiogenin may be a valuable marker of differential diagnosis of GTDs and its serial measurements are suggestive of remission and effective therapeutic intervention or disease progression." 03/01/2003 - "Serial angiogenin assays were correlated with disease progression and were positively correlated with serum hCGb (r = 0.75, p < 0.01). " 01/01/2020 - "5'ValCAC was quantified in spinal cord and serum from SOD1G93A amyotrophic lateral sclerosis mouse models where we found it to be significantly elevated at symptom onset correlating with increased angiogenin expression, imbalanced protein translation initiation factors and slower disease progression. " 11/01/2015 - "In addition, the level of angiogenin in primary breast carcinomas correlated with clinical progression. " 07/01/2004 - "Serum angiogenin is not elevated in patients with early B-cell chronic lymphocytic leukemia but is prognostic factor for disease progression."

Related Drugs and Biologics

1.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
2.	Peptides (Polypeptides)
3.	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
4.	Messenger RNA (mRNA)
5.	Angiopoietins
6.	Angiostatins
7.	Monoclonal Antibodies
8.	Immunoglobulin M (IgM)
9.	Fibroblast Growth Factor 1 (FGF-1)
10.	Albumins

Related Therapies and Procedures

1.	Percutaneous Coronary Intervention
2.	Prostatectomy (Retropubic Prostatectomy)
3.	Renal Dialysis (Hemodialysis)
4.	Therapeutics
5.	Drug Therapy (Chemotherapy)