|1.||Liaudet, Lucas: 1 article (07/2008)|
|2.||Marino, Mathieu: 1 article (07/2008)|
|3.||Diaceri, Giacomo: 1 article (07/2008)|
|4.||Tolsa, Jean-François: 1 article (07/2008)|
|5.||Muehlethaler, Vincent: 1 article (07/2008)|
|6.||Peyter, Anne-Christine: 1 article (07/2008)|
|7.||Di Bernardo, Stefano: 1 article (07/2008)|
|1.||Duodenal Ulcer (Curling's Ulcer)
12/15/1989 - "Three different doses of the M1-selective antimuscarinic compound telenzepine were investigated in the treatment of acute duodenal ulcer in a randomized, double-blind dose-range finding study. "
12/15/1989 - "[Dose finding study of telenzepine (1.5 vs. 3 vs 5 mg once daily) in acute treatment of duodenal ulcer. "
12/15/1989 - "In four investigating centers, 120 patients with endoscopically proven, florid duodenal ulcer were treated with either 1.5 mg, 3 mg or 5 mg telenzepine once daily at bedtime (40 patients per dose group). "
04/01/1989 - "[Single evening administration of a new antimuscarinic agent telenzepine in therapy of acute duodenal ulcer. "
04/01/1989 - "The present study shows for the first time that the newly developed antimuscarinic drug telenzepine is in a single nocturnal dosage regimen (3 mg nocte) as effective as pirenzepine (50 mg bid) in the treatment of duodenal ulcer."
|2.||Asthma (Bronchial Asthma)
04/01/1994 - "The results of this study indicate that the use of telenzepine via the oral route at a dose of up to 5 mg is not effective in preventing nocturnal asthma."
04/01/1994 - "Effect of telenzepine, an M1-selective muscarinic receptor antagonist, in patients with nocturnal asthma."
04/01/1994 - "The aim of the present study was to investigate whether telenzepine, an M1-selective muscarinic receptor antagonist, administered orally at different doses (1.5 mg, 3 mg, 5 mg) for one week, reduced airway obstruction in patients with nocturnal asthma in comparison with placebo. "
|3.||Airway Obstruction (Choking)
12/15/1989 - "These results show that telenzepine dose-dependently accelerates ulcer healing and that maximal effect is obtained with the 3-mg dose. "
06/08/1989 - "The data are compatible with the blockade of M1 receptors by (+)-telenzepine being responsible for this action of telenzepine and would tend to exclude the possibility that the anti-ulcer action of telenzepine is mediated via a muscarinic or non-muscarinic action of the (-) enantiomer."
02/01/1990 - "The two groups were similar with regard to age, sex, number of patients with ulcer recurrence, smoking habits etc. After 4 weeks treatment 51/80 patients (64%) healed on telenzepine 3 mg nocte and 49/83 patients (59%) on ranitidine 300 mg nocte. "
01/01/1986 - "In patients with duodenal ulcer 3 mg telenzepine nocte seems to be as effective as 50 mg pirenzepine twice daily in regard to ulcer healing and pain relief. "
01/01/1990 - "Overall and on a molar basis, ulcer healing was comparably accelerated by pantoprazole, omeprazole and telenzepine and less so by cimetidine. "
06/07/1985 - "The new antisecretory drug, telenzepine (4,9-dihydro-3-methyl-4-[(4-methyl-1-piperazinyl)acetyl]-10H-thieno-[3,4 - b][1,5]benzodiazepin-10-one), was investigated for its inhibition of functionally intact muscarinic receptors involved in gastric acid secretion in rabbit fundic glands, perfused mouse stomach in vitro, perfused rat stomach in situ, gastric fistula in rats and dogs with a Heidenhain pouch. "
03/01/1990 - "In conscious dogs with a gastric fistula we compared the action of different doses of telenzepine (ranging from 1 to 243 nmol/kg/h) and pirenzepine (ranging from 4.7 to 1170 nmol/kg/h) on gastric acid output in response to pentagastrin (1 to 8 micrograms/kg/h). "
11/01/1989 - "Telenzepine was found to be from 3 to 10 times more potent than pirenzepine in inhibiting bethanechol-, pentagastrin- and dimaprit-induced acid secretion in the conscious gastric fistula cat. "
01/01/1989 - "None of these antimuscarinics affected gastric acid secretion induced by histamine but all of them caused a dose-dependent inhibition of acid secretion from the gastric fistula (GF) and Heidenhain pouches (HP) stimulated by pentagastrin and bethanechol, telenzepine being 5-9 times more potent than pirenzepine and equipotent with atropine. "
|3.||Muscarinic Receptors (Muscarinic Acetylcholine Receptor)