sarsasapogenin

RN given refers to cpd without isomeric designation; a neurotrophic factor; structure given in first source

Also Known As:

PYM 50028; PYM-50028; PYM50028; epi-sarsasapogenin; epismilagenin; sarsaponin; sarsasapogenin, (3beta,5alpha,25R)-isomer; sarsasapogenin, (3beta,5alpha,25S)-isomer; sarsasapogenin, (3beta,5beta)-isomer; sarsasapogenin, (3beta,5beta,25R)-isomer; sarsasapogenin, (3beta,5beta,25S)-isomer; smilagenin; tigogenin

Networked: 48 relevant articles (8 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Cholestanes
      - Spirostans
        sarsasapogenin: 48

Experts

1.	Liu, Yao-Wu: 6 articles (10/2021 - 08/2018)
2.	Mandlik, Satish K: 3 articles (12/2021 - 04/2020)
3.	Ma, Teng-Fei: 3 articles (10/2021 - 11/2020)
4.	Zhang, Yu-Meng: 3 articles (10/2021 - 11/2020)
5.	Kong, Li: 3 articles (06/2021 - 08/2018)
6.	Ma, Lei: 3 articles (10/2019 - 06/2017)
7.	Wang, Rui: 3 articles (10/2019 - 06/2017)
8.	Zhang, Rui: 3 articles (01/2019 - 09/2007)
9.	Song, Shaojiang: 3 articles (05/2018 - 02/2017)
10.	Wang, Shaojie: 3 articles (05/2018 - 02/2017)

Related Diseases

1.	Diabetic Nephropathies (Diabetic Nephropathy) 09/01/2019 - "Protective effects of sarsasapogenin against early stage of diabetic nephropathy in rats." 08/01/2018 - "Protective effects of sarsasapogenin against early stage of diabetic nephropathy in rats." 08/01/2018 - "This study was designed to investigate the effects of sarsasapogenin (Sar), a major sapogenin from AA, on diabetic nephropathy (DN) in rats, and to explore the possible mechanisms. " 10/01/2021 - "Sarsasapogenin restores podocyte autophagy in diabetic nephropathy by targeting GSK3β signaling pathway." 11/01/2020 - "Sarsasapogenin alleviates diabetic nephropathy through suppression of chronic inflammation by down-regulating PAR-1: In vivo and in vitro study."
2.	Inflammation (Inflammations) 02/01/2021 - "Sarsasapogenin improves adipose tissue inflammation and ameliorates insulin resistance in high-fat diet-fed C57BL/6J mice." 11/01/2020 - "Sarsasapogenin alleviates diabetic nephropathy through suppression of chronic inflammation by down-regulating PAR-1: In vivo and in vitro study." 06/01/2017 - "Sarsasapogenin has been reported to improve dementia symptoms somehow, probably through modulating the function of cholinergic system, suppressing neurofibrillary tangles, and inhibiting inflammation. " 04/01/2020 - "Combination of Sarsasapogenin and Fluticasone attenuates ovalbumin-induced airway inflammation in a mouse asthma model."
3.	Schizophrenia (Dementia Praecox) 08/01/2011 - "OBJECTIVE To identify whether sarsasapogenin, a sapogenin from the Chinese medicinal herb Anemarrhena Asphodeloides Bunge, would augment the efficacy of risperidone and significantly improve cognitive functions in patients with negative symptoms dominated schizophrenia. " 08/01/2011 - "CONCLUSION Sarsasapogenin did not augment the efficacy of risperidone in treating negative symptoms dominated schizophrenia. " 08/01/2011 - "Sarsasapogenin at a dosage of 200 mg per day added to a flexible dosage of risperidone at 2-4 mg per day is safe and well tolerated by patients with negative symptoms dominated schizophrenia." 08/01/2011 - "A double-blind, placebo-controlled study of traditional Chinese medicine sarsasapogenin added to risperidone in patients with negative symptoms dominated schizophrenia."
4.	Neoplasms (Cancer) 01/01/2018 - "Two series of new sarsasapogenin derivatives were synthesized and evaluated for their cytotoxicities against three human cancer cell lines (HepG2, A549, MCF-7) using the MTT assay. " 01/01/2015 - "The pharmacological results showed that most of the sarsasapogenin derivatives displayed excellent selective cytotoxicity toward the cancer cell lines. " 01/01/2015 - "Based on the fact that timosaponin A-III (TA-III) exhibits potent cytotoxic effects and has been considered as a potential anti-tumor agent, a range of novel sarsasapogenin derivatives 1, 2a-2g, 3, 4, 5, 6a-6g have been synthesized by a simple and facile synthetic route. " 01/01/2015 - "Synthesis and biological evaluation of novel sarsasapogenin derivatives as potential anti-tumor agents." 02/15/2017 - "Based on the fact that Timosaponin A-III, a saponin isolated from the rhizome of Anemarrhena asphodeloides, is a promising bioactive lead compound in the treatment of cancer, structural modification at the C3 and C26 positions of sarsasapogenin has always been the focus of our structure-activity investigations. "
5.	Asthma (Bronchial Asthma) 04/01/2020 - "Combination of Sarsasapogenin and Fluticasone attenuates ovalbumin-induced airway inflammation in a mouse asthma model." 10/01/2021 - "Sarsasapogenin (SG), as an active component, has been found in many plants, and it exhibits potential protective effects, such as anti-inflammatory, antioxidant, anti-psoriasis, anti-arthritis, anti-asthma, anti-depressant and anti-cancer. "

Related Drugs and Biologics

1.	Risperidone (Risperdal Consta)
2.	PAR-1 Receptor
3.	Cholinergic Agents (Cholinergics)
4.	Antioxidants
5.	Fluticasone (Cutivate)
6.	Retinal Pigments (Pigments, Visual)
7.	Dinitrofluorobenzene
8.	Saponins
9.	hecogenin
10.	Diosgenin

Related Therapies and Procedures

1.	Chinese Traditional Medicine (Traditional Chinese Medicine)
2.	Therapeutics
3.	Drug Therapy (Chemotherapy)