sodium carbonate drug combination sodium bicarbonate

10/01/1994 - "However, the potential therapeutic advantage of Carbicarb remains to be determined, especially in patients with more severe metabolic acidosis."
11/01/1987 - "Carbicarb: an effective substitute for NaHCO3 for the treatment of acidosis."
05/01/1989 - "Carbicarb therapy resulted in systemic alkalinization without major changes in arterial PCO2 and intracellular brain alkalinization in both acidosis models. "
01/01/1988 - "Improved hemodynamic function during hypoxia with Carbicarb, a new agent for the management of acidosis."
04/01/1991 - "Metabolic acidosis (pH 7.20) and alkalosis (pH 7.60) were induced with HCl and Carbicarb (isosmolar Na2CO3 and NaHCO3), respectively. "

12/01/1989 - "Brain pH effects of NaHCO3 and Carbicarb in lactic acidosis."
01/01/1988 - "We studied the effects of carbicarb in an animal preparation of hypoxic lactic acidosis (HLA). "
02/01/1996 - "The present study was designed to investigate whether Carbicarb or NaHCO3 is superior to normal saline in the treatment of hypoxic lactic acidosis. "
02/01/1996 - "Effects of Carbicarb and sodium bicarbonate on hypoxic lactic acidosis in newborn pigs."
09/01/1993 - "The data suggest that Carbicarb administration in hypoxic lactic acidosis improved hemodynamics compared with sodium bicarbonate or sodium chloride administration. "

01/01/1988 - "The liver pHi (normal = 6.99, hypoxia = 6.80) improved with carbicarb (to 6.92), but decreased further with NaHCO3 (to 6.40). "
02/01/1996 - "When the pH fell to < 7.2, hypoxia was reversed by placing the animals in 21% O2 (experiment 1) or 100% O(2) (experiment 2) and either saline, Carbicarb or NaHCO3 were given. "
01/01/1988 - "Improved hemodynamic function during hypoxia with Carbicarb, a new agent for the management of acidosis."
01/01/1988 - "Dogs with HLA (n = 28) were then treated with 2.5 meq/kg of either NaHCO3 or carbicarb over 1 hr. Measurements were made, after 1 hr of hypoxia and 1 hr of therapy, of: cardiac hemodynamics, blood gases, liver intracellular pH (pHi), oxygen consumption, and regional lactate production. "

04/01/1991 - "Metabolic acidosis (pH 7.20) and alkalosis (pH 7.60) were induced with HCl and Carbicarb (isosmolar Na2CO3 and NaHCO3), respectively. "
01/01/2001 - "Our results suggest that agents such as sodium bicarbonate, Carbicarb and the diuretic furosemide--which are known to induce metabolic alkalosis in humans--may be useful in enhancing the efficacy of these treatment regimens in humans."

11/01/2002 - "Group 3 Carbicarb animals demonstrated improvements in brain pH(i), rCBF, and NADH fluorescence, with a significant reduction in infarct volume. "