|1.||Lanaspa, Miguel A: 6 articles (11/2014 - 01/2012)|
|2.||Johnson, Richard J: 6 articles (11/2014 - 01/2012)|
|3.||Ishimoto, Takuji: 6 articles (11/2014 - 01/2012)|
|4.||Rivard, Christopher J: 4 articles (11/2014 - 01/2012)|
|5.||Cicerchi, Christina: 4 articles (11/2014 - 01/2012)|
|6.||Sanchez-Lozada, Laura G: 3 articles (11/2014 - 01/2012)|
|7.||Rodriguez-Iturbe, Bernardo: 3 articles (11/2014 - 01/2012)|
|8.||Sautin, Yuri Y: 3 articles (11/2014 - 01/2012)|
|9.||Inaba, Shinichiro: 3 articles (11/2014 - 11/2013)|
|10.||Roncal-Jimenez, Carlos A: 3 articles (11/2014 - 01/2012)|
11/01/2014 - "In contrast, diabetic fructokinase-deficient mice demonstrated significantly less proteinuria, renal dysfunction, renal injury, and inflammation. "
11/01/2013 - "Both wild-type and fructokinase knockout mice developed obesity with mild hepatic steatosis and no evidence of hepatic inflammation on a high-fat diet compared to a low-fat diet. "
02/15/2011 - "Reduction of liver fructokinase expression and improved hepatic inflammation and metabolism in liquid fructose-fed rats after atorvastatin treatment."
01/15/2013 - "Thus, we demonstrate for the first time that the specific PPAR-δ agonist GW0742 attenuates the metabolic abnormalities and the renal dysfunction/inflammation caused by chronic HFCS-55 exposure by preventing upregulation of fructokinase (liver) and activation of the NLRP3 inflammasome (kidney)."
|2.||Dehydration (Water Stress)
08/01/2014 - "Clinical and pathological similarities between this injury model and endemic Mesoamerican nephropathy (MeN) have fueled speculation that dehydration-induced injury and MeN may share common mechanistic underpinnings involving fructokinase that can be targeted to mitigate disease development, progression, and/or severity. "
08/01/2014 - "Wild-type and fructokinase-deficient mice were subjected to recurrent heat-induced dehydration. "
08/01/2014 - "Fructokinase activity mediates dehydration-induced renal injury."
08/01/2014 - "This effect is attenuated by global fructokinase deficiency, suggesting possible roles for fructokinase and fructose metabolism in mediating or promoting dehydration-induced injury. "
05/01/2001 - "In contrast to hexokinase, fructokinase activity was unchanged during dehydration. "
|3.||Diabetic Nephropathies (Diabetic Nephropathy)
11/01/2014 - "These studies identify fructokinase as a novel mediator of diabetic nephropathy and document a novel role for endogenous fructose production, or fructoneogenesis, in driving renal disease. "
11/01/2014 - "In this study, we investigated the potential role of endogenous fructose production, as opposed to dietary fructose, and its metabolism through fructokinase in the development of diabetic nephropathy. "
11/01/2014 - "Endogenous fructose production and fructokinase activation mediate renal injury in diabetic nephropathy."
11/01/2013 - "Here we tested the hypothesis that fructose may interact with a high-fat diet to induce fatty liver, and to determine if this was dependent on a key enzyme in fructose metabolism, fructokinase. "
11/01/2013 - "High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase."
11/01/2013 - "The protection in fructokinase knockout mice suggests a key role for fructose (from sucrose) in this development of steatohepatitis. "
01/01/2012 - "Uric acid stimulates fructokinase and accelerates fructose metabolism in the development of fatty liver."
03/15/2013 - "Systemic blood pressure, plasma UA, triglycerides (TG), glucose and insulin, glomerular hemodynamics, renal structural damage, renal cortex and liver UA, TG, markers of oxidative stress, mitDNA, fructokinase, and fatty liver synthase protein expressions were evaluated at the end of the experiment. "
01/15/2013 - "In the liver, HFCS-55 enhanced the expression of fructokinase resulting in hyperuricemia and caused abnormalities in known insulin-driven signaling events. "
01/01/2015 - "Three major potential mechanisms have been identified, including the effects of vasopressin on the kidney, the activation of the aldose reductase-fructokinase pathway, and the effects of chronic hyperuricemia. "
|1.||Fat-Restricted Diet (Diet, Fat Restricted)