|1.||Galabov, A S: 1 article (04/2000)|
|2.||Nikolaeva, L: 1 article (04/2000)|
05/01/1989 - "At 200 mg/kg per day, disoxaril significantly decreased the incidence of clinical disease, i.e., paralysis and death. "
01/01/1986 - "An oral four times a day dosage regimen initiated 48 h postinfection with WIN 51711 doses as low as 12.5 mg/kg was effective in significantly reducing poliovirus-induced paralysis and death compared with a placebo. "
10/01/1986 - "Single, daily intraperitoneal doses of WIN 51711 as low as 10 mg/kg significantly (P less than .01) slowed the rate of onset of echovirus-induced paralysis and reduced the number of paralyzed animals. "
10/01/1986 - "Use of WIN 51711 to prevent echovirus type 9-induced paralysis in suckling mice."
01/01/1986 - "WIN 51711, a new broad-spectrum anti-picornavirus agent, prevented the development of paralysis and subsequent death in mice infected intracerebrally with a lethal dose of human poliovirus type 2 (MEF strain). "
05/01/1989 - "In this study, the efficacy of the antienterovirus (and antipicornavirus) drug disoxaril was demonstrated in a murine model of persistent enterovirus infection. "
05/01/1989 - "Clearance of a persistent human enterovirus infection of the mouse central nervous system by the antiviral agent disoxaril."
12/15/1993 - "The procapsids are useful in serological diagnosis of enterovirus infections, and the addition of disoxaril facilitates this technique."
01/01/1986 - "The potent in vitro and in vivo anti-picornavirus activity of WIN 51711 makes it a potentially useful drug for the treatment of enterovirus infections in humans."
04/01/2000 - "Effects of enviroxime and disoxaril, inhibitors of replication of some picornaviruses with known mechanisms of action, alone or in combination, on replication of coxsackievirus B1 (CVB1) in FL cells and on experimental CVB1 infection in newborn mice were tested. "
04/01/2000 - "Antiviral effect of the combination of enviroxime and disoxaril on coxsackievirus B1 infection."
10/01/1986 - "Oral administration of WIN 51711 twice daily beginning 72 hr after infection was the most-effective dosage regimen, with doses as low as 3 mg/kg preventing paralysis in 75% of the animals. "