broxaterol

RN given refers to parent cpd

Also Known As:

1-(3-bromo-5-isoxazolyl)-2-(tert-butylamino)ethanol hydrochloride; broxaterol monohydrochloride; broxaterol monohydrochloride, (+)-isomer; broxaterol monohydrochloride, (-)-isomer; broxaterol, (+)-isomer; broxaterol, (+-)-isomer; broxaterol, (-)-isomer

Networked: 21 relevant articles (3 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Isoxazoles: 155
      - broxaterol: 21

Related Diseases

1.	Asthma (Bronchial Asthma) 01/01/1988 - "Early bronchodilating effect of a new oral beta-2-receptor agonist (broxaterol) in bronchial asthma." 03/01/1989 - "[Efficacy of broxaterol (vs salbutamol) in asthma induced by physical exercise in children]." 06/28/1991 - "In this work we study this process by using two model drug substances, scopolamine (already well known as a transdermally active substance) and broxaterol, a new drug against asthma. " 09/01/1993 - "Eleven subjects 18 to 50 yr of age with mild asthma inhaled albuterol (200 micrograms), broxaterol (400 micrograms), or placebo three times a day for 3 wk with a 2- to 4-wk run-in/washout period between treatments. " 01/01/1990 - "The bronchodilating activity and tolerability of broxaterol and salbutamol administered by pressurized metered dose inhalers have been compared in 9 adult patients with bronchial asthma and clinically stable and reversible bronchospasm. "
2.	Fatigue 01/01/1997 - "In contrast, salbutamol did not alter Pdi at 20 Hz. Neither drug affected Pdi at 100 Hz. We conclude that broxaterol promoted recovery of low-frequency fatigue of the canine diaphragm in vivo in a dose-dependent manner, whereas salbutamol only minimally improved force production by the fatigued diaphragm." 01/01/1997 - "After stabilization of fatigue, the animals received a bolus (18.5 microg/kg) of either broxaterol or salbutamol, followed by a continuous infusion (0.43 microg/kg/min). " 07/01/1992 - "We conclude that (1) broxaterol promotes recovery of low-frequency fatigue in a dose-dependent way, and (2) theophylline does not improve the force output of fatigued canine diaphragm in vivo."
3.	Exercise-Induced Asthma (Asthma, Exercise Induced) 03/01/1989 - "In conclusion our data confirms the Broxaterol efficacy in exercise-induced asthma prevention." 01/01/1989 - "Broxaterol 0.5 mg by oral route provided a significant greater protection against the exercise-induced bronchospasm than 0.02 mg of clenbuterol and a placebo. " 01/01/1989 - "Also in children, broxaterol 0.25 mg as nebulizer solution significantly prevented exercise-induced bronchospasm versus placebo, and this effect was seen to be associated with an improvement in maximal working capacity. "
4.	Bronchial Spasm 05/01/1988 - "[Protective action of broxaterol in bronchial spasm induced by ultrasonic mist]." 07/01/1987 - "[Evaluation of the effectiveness and tolerance of broxaterol in 10 patients with reversible bronchospasm]." 01/01/1985 - "10 patients with reversible bronchospasm received by the oral route in a double-blind fashion broxaterol, Z. " 01/01/1989 - "Prevention of bronchospasm following 3 or 4 consecutive challenges with inhaled distilled water mist was demonstrated after oral and aerosol administration of broxaterol. " 01/01/1989 - "[Effectiveness of a new beta 2-agonist (broxaterol) on bronchospasm induced by methacholine (blind study versus salbutamol)]."
5.	Bronchitis 12/01/1995 - "The aim of our study was to evaluate the effect of the iv administration of two different beta 2- receptors agonists, salbutamol and broxaterol, on the growth hormone (GH) response to maximal exercise in 11 patients (8 males and 3 females; age range 18-65 yr; mean +/- SE age 56 +/- 13 yr; BMI 26.2 +/- 1.4 kg/m2) with chronic asthmatic bronchitis. " 12/01/1995 - "Effect of two beta 2-agonist drugs, salbutamol and broxaterol, on the growth hormone response to exercise in adult patients with asthmatic bronchitis." 02/01/1988 - "In 12 adult patients with reversible bronchospasm (7 bronchial asthma and 5 chronic obstructive bronchitis) the bronchodilator activity and tolerability of 200 and 400 mcg of broxaterol hydrochloride (Z 1170) were compared to those of 200 mcg of salbutamol administered by metered-dose inhaler. "

Related Drugs and Biologics

1.	Albuterol (Salbutamol)
2.	Solutions
3.	Clenbuterol
4.	Methacholine Chloride (Methacholine)
5.	Growth Hormone (Somatotropin)
6.	Scopolamine (Hyoscine)
7.	Aerosols
8.	Oral Sprays
9.	Procaterol (Pro-Air)
10.	Theophylline (Theon)

Related Therapies and Procedures

1.	Nebulizers and Vaporizers (Inhaler)
2.	Metered Dose Inhalers (Metered Dose Inhaler)