neo-gambogic acid

from Gamboge (Garcinia hanburryi); structure given in first source

Also Known As:

gambogenic acid; neogambogic acid; 2-Butenoic acid, 4-(3a,4,5,7,10,11-hexahydro-8,9-dihydroxy-3,3,11-trimethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-methano-1H,3H,9H-furo(3,4-g)pyrano(3,2-b)xanthen-1-yl)-2-methyl-

Networked: 47 relevant articles (1 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Xanthenes: 65
      - neo-gambogic acid: 47

Experts

1.	Cheng, Hui: 8 articles (01/2022 - 03/2012)
2.	Li, Qinglin: 5 articles (01/2022 - 02/2011)
3.	Chen, Weidong: 4 articles (01/2021 - 12/2018)
4.	Su, Jingjing: 4 articles (01/2020 - 02/2011)
5.	Li, Qing-Lin: 4 articles (11/2018 - 01/2012)
6.	Zhang, Hongming: 3 articles (03/2019 - 01/2017)
7.	Chen, Baoan: 3 articles (01/2017 - 10/2016)
8.	Wang, Meng: 2 articles (01/2022 - 01/2020)
9.	Dong, Qiannian: 2 articles (01/2021 - 09/2020)
10.	Wang, Beilei: 2 articles (01/2021 - 09/2020)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2023 - "Herein, we report a charge-reversible nanoparticles of gambogenic acid (CRNP-GNA) that would induce the positive feedback loop between increased tumor vascular permeability and improved drug accumulation. " 01/01/2013 - "Gambogenic acid anti-cancer activity in vitro has been reported in several studies, including an A549 nude mouse model. " 02/10/2011 - "In the present study, Gambogenic acid exhibits potential anti-tumor activity in several cancer cell lines. " 05/01/2023 - "Gambogenic acid (GNA), which has a broad spectrum of anti-tumor activity, is considered as a potential anticancer ingredient. " 01/01/2022 - "Gambogenic acid (GNA) is extracted from plant Gamboge, has a wide range of anti-tumor effects. "
2.	Melanoma (Melanoma, Malignant) 01/01/2023 - "In our previous studies, gambogenic acid (GNA) inhibited the proliferation and migration of melanoma cells. " 05/01/2017 - "The aim of the present study was to explore the effects of gambogenic acid (GNA) on the malignant behaviors of choroidal melanoma cells, including cell viability, cell cycle, migration and invasion, and to elucidate the underlying regulatory mechanism. " 10/01/2022 - "The levels of Furthermore, NEAT1 decrease under the treatment of Gambogenic acid (GNA), a promising natural anticancer compound, while NEAT1 overexpression suppresses GNA inhibition on cell vitality and eliminates GNA-induced melanoma cell ferroptosis and autophagy." 10/01/2022 - "The results showed that gambogenic acid (GNA) could inhibit the proliferation of melanoma cells in vivo (C57BL/6 mice) and in vitro. " 01/01/2020 - "Gambogenic acid induces ferroptosis in melanoma cells undergoing epithelial-to-mesenchymal transition."
3.	Experimental Melanoma 05/01/2014 - "[Study of gambogenic acid-induced apoptosis of melanoma B16 cells through PI3K/Akt/mTOR signaling pathways]." 03/01/2014 - "To study the inhibitory effect of Gambogenic acid (GNA) on melanoma B16 cells proliferation, and to explore the role of cell apoptosis. " 06/19/2020 - "Neogambogic acid can inhibit the proliferation, invasion and migration of melanoma B16 cells and induce their apoptosis, which may be regulated via the PI3K/Akt/mTOR signaling pathway." 06/19/2020 - "Melanoma B16 cells were treated with different concentrations of neogambogic acid solutions (0, 1.5, 3.0, 6.0 μM). " 06/19/2020 - "To explore the mechanism by which melanoma B16 cell apoptosis was induced by neogambogic acid. "
4.	Lung Neoplasms (Lung Cancer) 01/01/2020 - "Gambogenic acid exerts anticancer effects in cisplatin‑resistant non‑small cell lung cancer cells." 03/01/2019 - "Gambogenic acid inhibits the proliferation of small‑cell lung cancer cells by arresting the cell cycle and inducing apoptosis." 11/01/2018 - "Gambogenic acid can inhibit angiogenesis in lung cancer in vitro, and the mechanism of inhibiting angiogenesis may be related to the PI3K/Akt signaling pathway." 11/01/2018 - "The aim of this paper was to observe the effect of gambogenic acid on angiogenesis of lung cancer and its preliminary mechanism. " 11/01/2018 - "[Mechanism of gambogenic acid in resisting angiogenesis of lung cancer in vitro]."
5.	Colorectal Neoplasms (Colorectal Cancer) 11/01/2023 - "The present study aims to investigate the mechanism of the nature compound gambogenic acid (GNA) on the apoptosis and ferroptosis in colorectal cancer (CRC). The effect of GNA on the proliferation of CRC cell lines were detected by MTT and clonogenic assay. " 11/01/2023 - "Gambogenic acid inhibits proliferation and ferroptosis by targeting the miR-1291/FOXA2 and AMPKα/SLC7A11/GPX4 axis in colorectal cancer." 08/15/2022 - "Neogambogic acid suppressed viability, the spheroid formation ability and the levels of CSC markers in colorectal cancer (CRC) cells, accompanied with inhibition of colony-formation and ALDH level, apoptosis induction and G0/G1 phase arrest. " 01/01/2021 - "Gambogenic Acid Induces Endoplasmic Reticulum Stress in Colorectal Cancer via the Aurora A Pathway." 11/01/2020 - "Gambogenic acid induces Noxa-mediated apoptosis in colorectal cancer through ROS-dependent activation of IRE1α/JNK."

Related Drugs and Biologics

1.	xanthone
2.	Cyclin D1
3.	Small Interfering RNA (siRNA)
4.	Cyclin E
5.	Gefitinib (Iressa)
6.	gambogic acid
7.	Long Noncoding RNA
8.	Proteins (Proteins, Gene)
9.	Folic Acid (Vitamin M)
10.	Doxorubicin (Adriamycin)

Related Therapies and Procedures

1.	Traditional Medicine (Folk Remedies)
2.	Therapeutics
3.	Oral Administration
4.	Radiotherapy
5.	Chinese Traditional Medicine (Traditional Chinese Medicine)