3-N-butyl-4,5-dihydrophthalide (NBPA)

from seeds of Apium graveolens Linn.; RN given refers to (-)-isomer; structure given in first source

Also Known As:

NBPA; 3-N-butyl-4,5-dihydrophthalide, (S)-isomer; sedanenolide; senkyunolide; senkyunolide A

Networked: 15 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzofurans: 26
      - 3-N-butyl-4,5-dihydrophthalide: 15

Experts

1.	Lin, Ge: 2 articles (10/2008 - 02/2007)
2.	Lv, Dongwei: 1 article (12/2022)
3.	Shao, Minglei: 1 article (12/2022)
4.	Sun, Haijun: 1 article (12/2022)
5.	Wang, Zhitao: 1 article (12/2022)
6.	Zhou, Kai: 1 article (12/2022)
7.	Chen, Yan: 1 article (01/2021)
8.	Chu, Furui: 1 article (01/2021)
9.	Duan, Xianchun: 1 article (01/2021)
10.	Fei, Changyi: 1 article (01/2021)

Related Diseases

1.	Colonic Neoplasms (Colon Cancer) 10/30/2008 - "In the present study, the cytotoxic and anti-proliferative effects of three main Angelica sinensis phthalides, namely n-butylidenephthalide (BLP), senkyunolide A (SKA) and z-ligustilide (LGT), and their synergy on colon cancer HT-29 cells were investigated. "
2.	Arthritis (Polyarthritis) 06/01/2016 - "A fast, sensitive, and reliable ultra-high performance liquid chromatography with tandem mass spectrometry method has been developed and validated for the simultaneous quantitation and pharmacokinetic study of five phthalides (senkyunolide A, ligustilide, butylidenephthalide, 3-butylphthalide, and levistilide A) in rat plasma after oral administration of Huo Luo Xiao Ling Dan (HLXLD) or Angelica sinensis--Ligusticum chuanxiong herb pair (DG-CX) between normal and arthritis rats. "
3.	Inflammation (Inflammations) 01/01/2020 - "These results suggest that senkyunolide A may cause the anti-inflammatory and hepatoprotective effects of COR by suppressing the genes involved in inflammation." 09/01/2005 - "Taken together, the results suggest that Z-ligustilide and senkyunolide A may have potential applications in the treatment of inflammation and related diseases based on their inhibitory activity on TNF-alpha production and TNF-alpha bioactivity. "
4.	Cardiovascular Diseases (Cardiovascular Disease) 02/01/2007 - "The pharmacokinetics of senkyunolide A, one of the major bioactive ingredients in the traditional Chinese medicinal herb Rhizoma Chuanxiong, which is commonly used for the treatment of cardiovascular diseases, was studied in rats. " 01/01/2014 - "In addition, biomarkers of cardiovascular diseases such as creatine kinase MB activity (CK-MB) and lactate dehydrogenase (LDH) as well as protein expression of both glutathione peroxidase and glutathione S-transferase π isozyme were assayed after treatment of rats with 0.2 mg/kg body weight of N-nitrosodibutylamine (NDBA), N-nitrosoethylbutylamine (NEBA), N-nitrosobutylpropylamine (NBPA), N-nitrosodiethylamine (NDEA), N-nitrosodimethylamine (NDMA), and N-nitrosodiphenylamine (NDPA) as a daily dose for two weeks. "
5.	Dandruff 12/01/2017 - "Reinforcement of barrier function and scalp homeostasis by Senkyunolide A to fight against dandruff."

Related Drugs and Biologics

1.	ligustilide
2.	butylidenephthalide
3.	huo luo xiao ling dan
4.	3-n-butylphthalide (butylphthalide)
5.	levistilide A
6.	Biomarkers (Surrogate Marker)
7.	MB Form Creatine Kinase
8.	Luteolin
9.	Transcription Factor AP-1 (Transcription Factor AP 1)
10.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)

Related Therapies and Procedures

1.	Oral Administration
2.	Aftercare (After-Treatment)