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hemoglobin Volga

Ala replaces Asp at position alpha2 beta2 27(B9)

Also Known As:

Hb Volga; Hemoglobin Volga

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Hemoglobins: 37188
      - Abnormal Hemoglobins: 120
        hemoglobin Volga: 5
  - Hemeproteins: 194
    - Globins: 2716
      - Hemoglobins: 37188
        Abnormal Hemoglobins: 120
        hemoglobin Volga: 5

Experts

1.	Amato, Antonio: 1 article (01/2017)
2.	Cappabianca, Maria Pia: 1 article (01/2017)
3.	Colosimo, Alessia: 1 article (01/2017)
4.	Dainese, Enrico: 1 article (01/2017)
5.	Di Biagio, Paola: 1 article (01/2017)
6.	Piscitelli, Roberta: 1 article (01/2017)
7.	Sabatucci, Annalaura: 1 article (01/2017)
8.	Sarra, Ofelia: 1 article (01/2017)
9.	Zei, Daniela: 1 article (01/2017)
10.	Altay, C: 1 article (08/2004)

Related Diseases

1.	Hemolytic Anemia 06/01/1993 - "Hb Volga was observed as a de novo mutation in a 5-year-old boy from Tuzla, Bosnia and Hercegovina, who exhibited severe Heinz body hemolytic anemia. " 08/01/2004 - "Severe hemolytic anemia associated with Hb Volga [beta27(B9)Ala-->Asp]: GCC-->GAC at codon 27 in a Turkish family."
2.	Reticulocytosis 01/01/1980 - "Hb Volga (beta 27 Ala replaced by Asp) on the basis of physical tests is only a mildly unstable hemoglobin yet it is associated with a gross reticulocytosis. "
3.	Thalassemia 01/01/2017 - "Among the other three described variants [Hb Volga (HBB: c.83C>A), Hb Knossos (HBB: c.82 G>T), Hb Grange-Blanche (HBB: c.83C>T] that are due to nucleotide substitutions at codon 27 of the β-globin gene; only Hb Knossos causes a β+-thalassemia (β+-thal) phenotype."
4.	Hemolysis 02/15/1991 - "A possible clue to the cause of the hemolysis is the increased vulnerability to oxidation of Hb Volga, with increased free radical turnover and consequent damage to the red cell membrane. "

Related Drugs and Biologics

1.	Codon (Codons)
2.	Nucleotides
3.	Hemoglobins (Hemoglobin)
4.	Globins
5.	Free Radicals
6.	alanylaspartic acid
7.	hemoglobin Knossos