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alpha-fluoro-beta-ureidopropionic acid (FUPA)
fluorouracil metabolite; structure given in first source
Also Known As:
FUPA
; 2-fluoro-3-ureidopropionic acid
Networked:
6
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amides: 2428
Urea: 15015
alpha-fluoro-beta-ureidopropionic acid: 6
Experts
1.
Johnson, Richard
: 1 article (01/2016)
2.
Pérez, Natalie
: 1 article (01/2016)
3.
Ramakrishnan, Girija
: 1 article (01/2016)
4.
Sen, Bhaswati
: 1 article (01/2016)
Related Diseases
1.
Neoplasms (Cancer)
01/01/1999 - "
Ex vivo measurements of tissue extracts from liver, kidney, and tumor indicated a >95% elimination of alpha-fluoro-beta-ureidopropionic acid and a-fluoro-beta-alanine signals in the tissues of mice that received 2 mg/kg of EU before administration of 5-FU.
"
12/01/1997 - "
The analysis of the NMR data revealed an increased formation and retention of fluorouracil nucleotides and fluorouridine in colon 38 tumors treated with the regimen containing BAU and a reduction in 5-FU catabolites (alpha-fluoro-beta-ureidopropionic acid and alpha-fluoro-beta-alanine).
"
01/01/1994 - "
The data analysed were relative concentrations of 5-fluorouracil (FU) and of the sum of its catabolites alpha-fluoro-beta-ureido-propanoic acid (FUPA) and alpha-fluoro-beta-alanine (FBAL) in the liver, as monitored in 16 cancer patients by [19F]-NMR spectroscopy during and after a 10-min intravenous infusion of 650 mg FU.m-2.
"
05/01/1991 - "
Using the CD8F1 murine mammary tumor as an in vivo model, we observed signals from FUra, alpha-fluoro-beta-alanine (F beta ALA), alpha-fluoro-beta-ureidopropionic acid (FUPA), and 5-fluorouracil-nucleotides (FUN) after intravenous or intraperitoneal injection of 150 mg/kg FUra.
"
2.
Tularemia
01/01/2016 - "
Iron acquisition mechanisms in Francisella tularensis, the causative agent of tularemia, include the Francisella siderophore locus (fsl) siderophore operon and a ferrous iron-transport system comprising outer-membrane protein FupA and inner-membrane transporter FeoB.
"
3.
Body Weight (Weight, Body)
06/01/1988 - "
In livers treated with low (30 mg/kg body weight (b.w.] or high (180 mg/kg b.w.) doses of FUra, with (180 mg/kg b.w.) or without thymidine (dThd), FUra was rapidly catabolized to alpha-fluoro-beta-ureidopropionic acid (FUPA) and alpha-fluoro-beta-alanine (FBAL), the latter usually becoming by far the major catabolite.
"
Related Drugs and Biologics
1.
alpha-fluoro-beta-ureidopropionic acid (FUPA)
2.
alpha-fluoro-beta-alanine (FBAL)
3.
Fluorouracil (Carac)
4.
Membrane Transport Proteins (Biological Pump)
5.
Siderophores
6.
beta-Alanine
7.
Tissue Extracts
8.
Thymidine
9.
Propionates
10.
Nucleotides
Related Therapies and Procedures
1.
Intraperitoneal Injections
2.
Intravenous Infusions