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SK&F 100330-A

structure given in first source

Also Known As:

N-(4,4-diphenyl-3-butenyl)guvacine; SKF-100330A

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Nicotinic Acids: 13
      - SK&F 100330-A: 1
- Heterocyclic Acids
  - Nicotinic Acids: 13
    - SK&F 100330-A: 1

Related Diseases

1.

Seizures (Absence Seizure)

07/01/1991 - "SK&F 100330-A provided complete protection against picrotoxin-induced seizures (s.c. "
07/01/1991 - "Intraperitoneal SK&F 100330-A provided complete protection against pentylenetetrazol-induced seizures [subcutaneous (s.c.) PTZ] in mice but was ineffective against seizures induced by maximal electroshock (MES) at doses slightly greater than its TD50. "
07/01/1991 - "Like intraperitoneal (i.p.) PHT, CBZ, VPA, and CZP, SK&F 89976-A and SK&F 100330-A inhibited seizures in corneally kindled rats. "
07/01/1991 - "Pic) and against both clonus and forelimb tonic extension induced by NMDA N-methyl-D-aspartate [intracerebral ventricular (i.c.v.)-NMDA] in mice; however, SK&F 100330-A was ineffective against seizures induced by bicuculline (s.c. "

Related Drugs and Biologics

1.	Picrotoxin
2.	Pentylenetetrazole (Metrazol)
3.	N-Methylaspartate (NMDA)
4.	Bicuculline
5.	N-(4,4-diphenyl-3-butenyl)nipecotic acid