leflunomide (Arava)

Subscribe to Selected New Research on leflunomide

578 relevant articles (82 outcomes, 109 trials/studies) found for this Drug

Description: inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway; antagonizes growth-factor mediated smooth muscle cell proliferation in vitro; structure given in first source

Also Known As:

Arava; SU101; Aventis Behring Brand of Leflunomide; Aventis Brand of Leflunomide; Aventis Pharma Brand of Leflunomide; HWA 486; HWA-486; Hoechst Brand of Leflunomide; N-(4-trifluoromethyphenyl)-5-methylisoxazole-4-carboxamide; 4-Isoxazolecarboxamide, 5-methyl-N-(4-(trifluoromethyl)phenyl)-

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 25

1-Ring Heterocyclic Compounds

Azoles: 243

Isoxazoles: 6

leflunomide: 578

Experts

1.	Strand, Vibeke: 8 articles (04/2005 - 01/2002)
2.	Strand, V: 7 articles (06/2004 - 03/2000)
3.	Emery, Paul: 6 articles (08/2005 - 02/2002)
4.	Smolen, J S: 6 articles (10/2003 - 06/2000)
5.	Emery, P: 6 articles (06/2003 - 05/2000)
6.	Rozman, B: 5 articles (02/2006 - 01/2001)
7.	Breedveld, F C: 5 articles (09/2004 - 07/2000)
8.	Schattenkirchner, M: 5 articles (06/2003 - 05/2000)
9.	Kraan, M C: 4 articles (01/2008 - 07/2000)
10.	van Roon, E N: 4 articles (08/2007 - 04/2005)

Related Diseases

1.	Rheumatoid Arthritis 10/01/2008 - "INTRODUCTION: Leflunomide is an immunomodulating agent with proven efficacy in rheumatoid arthritis. " 11/01/2000 - "In phase II and III clinical trials of active rheumatoid arthritis, leflunomide was shown to improve primary and secondary outcome measures with a satisfactory safety profile. " 12/01/2002 - "It has been shown that leflunomide is effective in treating active rheumatoid arthritis(RA) in a placebo-controlled phase II study. " 04/01/2002 - "Leflunomide, a new oral immunomodulatory agent, is effective for the treatment of rheumatoid arthritis. " 08/01/1998 - "The mammalian homologue of Prp16p is overexpressed in a cell line tolerant to Leflunomide, a new immunoregulatory drug effective against rheumatoid arthritis." Order ALL the reference details at left...
2.	Autoimmune Diseases (Autoimmune Disease) 01/01/1991 - "Thus, leflunomide, which is effective against autoimmune diseases and reactions leading to graft rejection, would seem to have a mode of action separating it from known immunosuppressive drugs." 11/01/2008 - "BACKGROUND/AIMS: Leflunomide is used in the treatment of autoimmune diseases as an anti-inflammatory agent. " 11/01/2004 - "Leflunomide is a novel immunosuppressive and anti-inflammatory agent for the treatment of autoimmune disease. " 09/15/2002 - "These results indicate that leflunomide might exert its anti-inflammatory activities in the treatment of autoimmune diseases by preventing the generation of proinflammatory Th1 effectors and promoting Th2 cell differentiation. " 02/15/1999 - "Leflunomide is a novel immunosuppressive and antiinflammatory agent currently being tested for treatment of autoimmune diseases and transplant rejection. " Order ALL the reference details at left...
3.	Psoriasis (Pustulosis Palmaris et Plantaris) 06/01/2004 - "Significant differences in favor of leflunomide were also observed in the proportions of patients achieving modified American College of Rheumatology 20% improvement criteria, improvement in the designated psoriasis target lesion, and mean changes from baseline in Psoriasis Area and Severity Index scores and quality-of-life assessments. " 12/01/2008 - "Is leflunomide effective in the treatment of psoriasis in a patient who is unable to benefit from standard first- and second-line therapies and needs an affordable treatment option?" 06/01/2004 - "CONCLUSION: Leflunomide is an effective treatment for PsA and psoriasis, providing a safe and convenient alternative to current therapies." 05/01/2004 - "CONCLUSIONS: Our data suggest that leflunomide for plaque-type psoriasis is a safe and clinically effective option as monotherapy. " 01/01/2006 - "BACKGROUND: Leflunomide has shown promise in the treatment of psoriasis. " Order ALL the reference details at left...
4.	Arthritis (Polyarthritis) 01/01/2005 - "CONCLUSION: In this open study of patients with active AS only those with peripheral arthritis improved significantly with leflunomide treatment. " 09/01/2004 - "Leflunomide was first shown to have disease-modifying properties in a rat model of adjuvant-induced arthritis. " 10/01/2002 - "Author's Reply to Leflunomide in Psoriatic Polyarthritis." 10/01/2002 - "Leflunomide in psoriatic polyarthritis." 02/01/2001 - "In August 1998, the Arthritis Advisory Committee unanimously recommended that leflunomide be contraindicatedfor pregnancy, and that a pregnancy registry should be established to monitor possible teratogenic effects of the drug [296187]. " Order ALL the reference details at left...
5.	Disease Progression 01/01/2003 - "This effect, coupled with its multiple inhibitory effects on T lymphocyte functions, might account for the significant reduction in the rate of disease progression in RA patients treated with leflunomide." 06/01/2000 - "Treatment with leflunomide results in significantly greater improvement of the signs and symptoms of RA than placebo for up to 2 yr and slows radiographically assessed disease progression. " 05/01/2000 - "Arava has a rapid onset of action and has been shown to retard radiographic disease progression and significantly improve patients' functional ability." 01/01/1999 - "The onset of action with leflunomide was rapid and was seen as early as Week 2. Radiographic disease progression was significantly slower with leflunomide than placebo (P < 0.01). " 01/01/1999 - "These data verify the ability of leflunomide to slow disease progression and confirm its disease-modifying potential." Order ALL the reference details at left...

Related Drugs and Biologics

1.	Methotrexate (Mexate)
2.	infliximab (Remicade)
3.	leflunomide (Arava)
4.	pyrimidine
5.	Sulfasalazine (Azulfidine)
6.	azastene
7.	Cyclosporine (Ciclosporin)
8.	Tacrolimus (Prograf)
9.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
10.	Cyclophosphamide (Cytoxan)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Transplants (Transplant)
3.	Drug Therapy (Chemotherapy)
4.	Organ Transplantation
5.	Subcutaneous Injections

Best Treatments:
Research Summary Report
on Rheumatoid Arthritis

CureHunter Patient-Physician Summary Reports collect in one document all the medications ever reported in the US National Library of Medicine—1949 to the present—to be effective against your target disease. CureHunter research summary reports will vary in length from 25 to 250 pages. Analytic charts allow you and your physicians to see at a glance your medication options—including new, promising, off-label and experimental all rated for clinical efficacy.

Free Updates for 1 Year
All 1565 Outcomes
Top 200 Key Drugs and Biologics
Top 50 Key Therapies and Procedures
Detailed History Charts
Full Research Reference Details
Sample PDF Report on Psoriasis >>

Price:

$24.00 & Delivery via PDF download
updates for 1 year

Research Interface

Rapidly retrieve summaries of all the evidence for any disease in seconds. Save hours of search and analysis time. CureHunter is unlike any "search engine" you have ever used. Where standard "search engines" produce lists of links, CureHunter quantifies evidence, extracts it from the literature and calculates a result you can use to immediately facilitate evidence based decision making in Real Clinical Time.

Unlimited Disease, Drug and Therapy Search
2 clicks from Disease to Drug to Evidence
Trial References
All the Positive Outcomes
Detailed Relationship Timeline Charts
Full Article Reference Details
Includes Mobile Interface Subscription
One-click to FDA Products/Patents
Request Institution License Details >>

Price:

$490.00 access via web interface
1 year subscription

Proceed to Checkout >>

Mobile Interface

Retrieve summaries of all the evidence for any disease from your Mobile Phone or PDA. Accelerate decision making in the field. Speed up your study of new drug and disease domains. Refresh your knowledge on the road.

Access from any web enabled PDA or Phone
Trial references
All the Positive Outcomes
Drug and Therapy searches
Full Article Reference Details
Try Mobile Interface >>

Price:

$45.00 access via "curehunter.com/m"
1 year subscription

Proceed to Checkout >>