U 69593

selective ligand for opioid K-receptor

Also Known As:

N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspiro(4,5)dec-8-yl)benzeneacetamide; U-69593; Benzeneacetamide, N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspiro(4.5)dec-8-yl)-, (5alpha,7alpha,8beta)-(-)-

Networked: 5 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - U 69593: 5
Organic Chemicals: 133
- Amides: 2428
  - Acetamides: 21
    - Benzeneacetamides
      - U 69593: 5
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzeneacetamides
        U 69593: 5

Experts

1.	Bai 白珊珊, Shan-Shan: 1 article (06/2022)
2.	Cao 曹烨, Ye: 1 article (06/2022)
3.	Fu 傅开元, Kai-Yuan: 1 article (06/2022)
4.	Liu 刘云, Yun: 1 article (06/2022)
5.	Mo 莫思怡, Si-Yi: 1 article (06/2022)
6.	Sessle, Barry J: 1 article (06/2022)
7.	Xie 谢秋菲, Qiu-Fei: 1 article (06/2022)
8.	Xu 徐啸翔, Xiao-Xiang: 1 article (06/2022)
9.	Gabrilovac, Jelka: 1 article (06/2002)
10.	Martin-Kleiner, Irena: 1 article (06/2002)

Related Diseases

1.	Hyperalgesia 06/03/2022 - "EOI-induced orofacial hyperalgesia could be relieved by EOI removal around postoperative day 3; this effect could be inhibited by intra-RVM microinjection of the kappa-opioid receptor agonist U-69593. " 01/01/2023 - "Mice received 3 daily doses of U-69593 or nalfurafine as a "first-hit" stimulus followed by assessment of periorbital tactile allodynia. "
2.	Mononeuropathies (Mononeuritis Multiplex) 06/01/1993 - "This study evaluated the antinociceptive effects of systemically administered selective opioid agonists of mu (DAMGO), delta (BUBU) and kappa (U 69593) receptors on the vocalization threshold to paw pressure in a rat model of peripheral unilateral mononeuropathy produced by loose ligatures around the common sciatic nerve. "
3.	Thymoma (Thymic Carcinoma) 06/01/2002 - "The kappa-opioid agonist U-69593 affects intracellular calcium level in R1.1 mouse thymoma cell line."
4.	Alzheimer Disease (Alzheimer's Disease) 01/01/1994 - "The binding of [3H]-U-69593 and [3H]-CI-977 to kappa-1 opioid receptors has been examined in the temporal cortex of postmortem brains from patients with Alzheimer's disease and age-matched controls using quantitative autoradiography. "

Related Drugs and Biologics

1.	kappa Opioid Receptors (kappa Opioid Receptor)
2.	Opioid Analgesics (Opioids)
3.	Ala(2)-MePhe(4)-Gly(5)- Enkephalin (DAGO)
4.	tyrosyl- seryl(O- t- butyl)- glycyl- phenylalanyl- leucyl- threonine(O- t- butyl) (BUBU)
5.	Opioid Receptors (Opioid Receptor)
6.	Calcium
7.	TRK 820
8.	enadoline

Related Therapies and Procedures

1.	Ligation