cefcanel daloxate (KY 109)

pro-drug to improve oral absorption of KY-087; structure given in first source

Also Known As:

KY 109; (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl-7(O-(alanyl)mandelamido)-3-((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl-3-cephem-4-carboxylate hydrochloride; KY-109; L-Alanine, 2-((2-(((5-methyl-2-oxo-1,3-dioxol-4-yl)methoxy)carbonyl)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-7-yl)amino)-2-oxo-1-phenylethyl ester, monohydrochloride, (6R-(6alpha,7beta(R*)))-

Networked: 4 relevant articles (2 outcomes, 2 trials/studies)

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Bio-Agent Context: Research Results

Related Diseases

1.	Urinary Tract Infections (Urinary Tract Infection) 01/01/1993 - "The clinical and bacteriologic efficacy of 3 days of cefcanel daloxate therapy, compared with 3 days of amoxicillin for the treatment of acute uncomplicated urinary tract infection was compared in a prospective randomized double-blind multicentre study. " 01/01/1993 - "These data suggest that cefcanel daloxate and amoxicillin are comparable as regards efficacy and adverse effects for 3-day therapy of acute uncomplicated urinary tract infection. "
2.	Infections 07/01/1988 - "The therapeutic efficacy of KY-109 against experimental intraperitoneal infections caused by Gram-positive and Gram-negative organisms in mice was comparable to that of CEX but inferior to that of CCL. " 07/01/1988 - "In experimental granuloma pouch models in rats and kidney infection in rabbits, therapeutic efficacy of KY-109 was either comparable or superior to that of CEX and CCL."
3.	Granuloma 07/01/1988 - "In experimental granuloma pouch models in rats and kidney infection in rabbits, therapeutic efficacy of KY-109 was either comparable or superior to that of CEX and CCL."
4.	Renal Insufficiency (Renal Failure) 02/01/1994 - "The present study investigated the pharmacokinetics of cefcanel following a single oral dose of cefcanel daloxate hydrochloride 300 mg to healthy volunteers and to patients with various degrees of stable renal insufficiency. "
5.	Maxillary Sinusitis 06/01/1995 - "A new oral prodrug cephalosporin, cefcanel daloxate, was compared with cefaclor, another oral cephalosporin, in the treatment of acute purulent maxillary sinusitis. "

Related Drugs and Biologics

1.	Amoxicillin (Wymox)
2.	cefcanel
3.	Prodrugs
4.	Cephalosporins (Cephalosporin Antibiotics)
5.	Cefaclor (Ceclor)

Related Therapies and Procedures

1.	Therapeutics

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