eupatilin

11/01/2018 - "Taken together, the results of the present study suggest that eupatilin serves neurological protective effects via inhibiting microglial inflammation, providing an experimental basis for the use of eupatilin as a therapeutic target for ICH."
05/01/2016 - "Eupatilin improved the acute hepatic IRI by reducing inflammation and apoptosis. "
11/01/2018 - "The aim of the present study was to investigate the effect of eupatilin on ICH-induced microglial inflammation. "
06/07/2023 - "This work focuses on the effects of Eupatilin (EUP) on inflammation reaction and the epithelial-to-mesenchymal transition (EMT) process in CRSwNP. "
03/01/2015 - "However, little is known about the molecular mechanism of eupatilin-induced attenuation of bronchial epithelium-induced inflammation. "

01/01/2021 - "Thus, eupatilin may be considered a novel therapeutic agent for the treatment of vocal fold fibrosis."
06/01/2020 - "The efficacy of eupatilin on TGF-β-induced endometrial fibrosis was assessed by examining changes in morphology and the expression levels of fibrosis markers using immunofluorescence staining and quantitative real-time reverse-transcription polymerase chain reaction. "
12/01/2023 - "Furthermore, eupatilin promoted Sestrin2 expression, and the knockdown of Sestrin2 significantly aggravated the degree of fibrosis, increased the phosphorylation of PI3K/Akt/mTOR, and decreased autophagy. "
03/21/2023 - "Furthermore, analysis of histopathological changes in the liver and markers of liver function and fibrosis revealed that hepatic fibrosis in CCl4-treated mice was markedly alleviated by eupatilin. "
06/01/2020 - "Our findings suggest that suppression of TGF-β-induced signaling by eupatilin might be an effective therapeutic strategy for the treatment of endometrial fibrosis."

02/01/2016 - "Therefore, eupatilin may have potential as an effective agent for the treatment of glioma."
01/01/2019 - "However, we did not observe the proapoptotic effect of eupatilin on glioma, which is inconsistent with other studies. "
02/01/2016 - "The results of the present study indicated that eupatilin exhibits an anticancer effect on glioma cells. "
02/01/2016 - "Therefore, in the current study the effects of eupatilin on glioma and the underlying molecular mechanism were explored. "
01/01/2019 - "Therefore, due to the poor clinical efficacy of drug treatment of glioma and high drug resistance, the emergence of eupatilin brings a new dawn for glioma patients."

06/01/2020 - "Eupatilin (5,7-dihydroxy-3',4',6-trimethoxyflavone) is a natural active substance found in génépi group plants, and its pharmacological activities has been proven to be useful in the treatment of various cancers. "
10/01/2015 - "Therefore, the present study aimed to investigate the effects of eupatilin on this malignant bone tumor, using the U-2 OS cell line. "
06/03/2020 - "Collectively, downregulating SERPINB11 with eupatilin against cancer progression may improve therapeutic activity."
01/01/2019 - "Eupatilin inhibited the growth of renal tumors in nude mice by downregulating miR-21. "
06/01/2018 - "Furthermore, treatment with eupatilin was found to decrease tumor volume in a TE1 xenograft mouse model, and the phosphorylation of Akt and ERK1/2 was inhibited by eupatilin in the tumor tissue. "

09/01/2009 - "Eupatilin, one of the pharmacologically active ingredients of Artemisia princeps, exhibits a potent anti-ulcer activity, but its effects on T-cell immunity have not been investigated. "
06/20/2011 - "Eupatilin (5,7-dihydroxy-3,4,6-trimethoxyflavone) is a pharmacologically active ingredients in Stillen(TM), a drug for the gastric mucosal ulcers. "
01/01/2015 - "The results indicated that extracts including eupatilin and extracts including quercetin-3-β-D-glucuronopyranoside dose-dependently improved the morphology of the lesions induced by 2,4,6-trinitrobenzene sulfonic acid and reduced the ulcer index accordingly. "
11/15/2011 - "These results suggest that countercurrent separation method can be applied to isolate two anti-ulcer flavonoids, eupatilin (1) and jaceosidin (2), selectively in one step, and to produce anti-ulcer flavonoid-enriched preparations."
04/01/2009 - "In the present study, we used cultured feline esophageal epithelial cells (EEC) to investigate the ability of eupatilin to induce expression of HO-1 and to analyze its cytoprotective effect against indomethacin-induced damage, since NSAID users have a higher risk of esophageal ulcers or esophagitis than non-NSAID users. "