05/01/1988 - "It is concluded that anipamil pretreatment protects the heart against some of the deleterious effects of ischemia and reperfusion. "
03/01/1986 - "Anipamil significantly reduced the elevated S-T segment elevation and T wave amplitude suggesting a moderating influence on cellular ischemia. "
05/01/1988 - "To assess whether the prophylactic administration of anipamil, a new calcium antagonist, protects the heart against the effects of ischemia and reperfusion, rats were injected intraperitoneally twice daily for 5 days with 5 mg/kg body weight of this drug. "
03/01/1992 - "Myocardial norepinephrine and glycogen stores were not decreased by pretreatment with anipamil, and their release or degradation due to ischemia and reperfusion were also not different from controls. "
05/01/1988 - "Pretreatment with anipamil altered neither left ventricular developed pressure under normoxic conditions nor the rate and extent of depletion of adenosine triphosphate (ATP) and creatine phosphate during ischemia. "
11/01/1994 - "The number of angina pectoris attacks was significantly reduced during treatment with anipamil 80 mg (p < 0.05) and anipamil 160 mg (p < 0.001) as compared with placebo. "
12/01/1993 - "Anipamil prevents ST depression in patients with stable angina pectoris."
11/01/1994 - "To evaluate the efficacy of anipamil, a phenylalkylamine calcium antagonist, in treatment of stable angina pectoris, we performed a randomized, double blind placebo-controlled, cross-over study. "
11/01/1994 - "Efficacy of anipamil, a phenylalkylamine calcium antagonist, in treatment of angina pectoris."
|3.||Hypertension (High Blood Pressure)
|4.||Myocardial Ischemia (Ischemic Heart Diseases)
01/01/1995 - "These results were used as a basis from which to choose doses for a second study to assess antiarrhythmic actions of anipamil against arrhythmias induced by regional myocardial ischemia. "
12/01/1993 - "In conclusion, anipamil given once a day is an effective 24-hour antiischemic drug in the treatment of transient myocardial ischemia."
01/01/1989 - "We conclude that pretreatment with anipamil reduces the functional and biochemical damage after acute myocardial ischemia and totally prevents reperfusion-induced arrhythmias in closed-chest rats."
01/01/1995 - "Effects of anipamil, a long acting analog of verapamil, in pigs subjected to myocardial ischemia."
01/01/1990 - "This study examined the effect of the long acting calcium antagonist anipamil on the extent of myocardial necrosis during 24 h of coronary artery occlusion in the dog. "
01/01/1990 - "Long acting calcium antagonist anipamil limits myocardial necrosis and penetrates the ischemic zone during 24 h of coronary artery occlusion in the dog."
02/01/1988 - "The protective effect of anipamil against isoprenaline-induced myocardial necrosis was definitely dose-dependent: 10 mg/kg anipamil exhibited a partial protective effect, whilst 20 mg/kg anipamil protected the heart completely."
02/01/1988 - "The new calcium antagonist anipamil (1,7-bis-(3-methoxyphenyl)-3-methylaza-7-cyano-nonadecane) exhibited a pronounced protective effect against isoprenaline-induced myocardial necrosis in rats. "
|3.||Adenosine Triphosphate (ATP)
|5.||Calcium Channels (Calcium Channel)