alpha- (1,4- dioxido- 3- methylquinoxalin- 2- yl)- N- methylnitrone

03/01/1994 - "In conclusion, the tumors of the esophagus induced by 2,6 DMNM under the influence of EJ are not only pure ADC and pure SCC, as we have previously reported, but also intermediate tumors showing either SCC with focal mucous or glandular differentiation (SCC + FGD) or ADC with areas of squamous cell differentiation (ADC + SCD).(ABSTRACT TRUNCATED AT 250 WORDS)"
06/01/1980 - "DMNM (total dose, 20 g/kg) produced liver tumors in 25 (69%) of the 36 rats and nasal cavity tumors in 9 (25%) of the rats. "
01/01/1978 - "DMNM was more toxic when administered sc, and the respiratory tract was the main target organ (with a 100% tumor incidence). "
01/01/1978 - "These studies indicated the importance of the treatment route but did not substantiate the role of common metabolites, such as DMNM, formed by beta-oxidation from DPN, with regard to induction of a given tumor type."
07/01/1995 - "Liver and/or glandular stomach neoplasms were produced by DMNM (liver and stomach), MNNG (stomach), and DBE (chiefly, stomach tumors). "

02/01/2001 - "In the present study Sprague-Dawley rats were given DMNM 15 days after performing an esophago-jejunostomy in order to induce chronic duodenal content reflux esophagitis. "
02/01/2001 - "We hypothesize that altered expression of cyclin D1 and p53 may be involved in the sequential development of esophageal carcinomas with glandular differentiation induced by the carcinogen, 2,6-dimethylnitrosomorpholine (DMNM) in rats with duodenal content reflux esophagitis. "

06/01/1981 - "The only other significant microscopic lesions consisted of mild testicular atrophy and occasional gastric erosions in dogs treated with 7.5 mg/kg/day of DMNM."
07/01/1995 - "In addition, DMNM produced a low incidence of swimbladder papillomas and caused testicular atrophy in 50% of treated males. "

02/01/2001 - "These findings suggest that overexpression of cyclin D1 may be an early event in DMNM-induced rat esophageal tumorigenesis, causing increased proliferation of esophageal stem cells. "

07/01/1995 - "Liver and/or glandular stomach neoplasms were produced by DMNM (liver and stomach), MNNG (stomach), and DBE (chiefly, stomach tumors). "