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iodosulpride
125I labeled; selective ligand for brain dopamine receptors; structure given in first source
Also Known As:
N-((1-cyclopropylmethyl-2-pyrrolidinyl)methyl)-2-methoxy-4-iodo-5-ethylsulfonylbenzamide; Benzamide, N-((1-(cyclopropylmethyl)-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-4-iodo-2-methoxy-
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amides: 2428
Benzamides: 115
Sulpiride: 752
iodosulpride: 3
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Benzoates: 426
Benzamides: 115
Sulpiride: 752
iodosulpride: 3
Carboxylic Acids: 973
Carbocyclic Acids
Benzoates: 426
Benzamides: 115
Sulpiride: 752
iodosulpride: 3
Experts
1.
Copolov, D L
: 1 article (05/2004)
2.
Dean, B
: 1 article (05/2004)
3.
Goeringer, K
: 1 article (05/2004)
4.
Pavey, G
: 1 article (05/2004)
5.
Scarr, E
: 1 article (05/2004)
Related Diseases
1.
Small Cell Lung Carcinoma (Small Cell Lung Cancer)
07/31/1989 - "
In the richest cell line N417, derived from small cell lung carcinoma, [125I] iodosulpride bound with a high affinity (Kd = 1.3 nM) to an apparently homogeneous population of binding site (Bmax = 1,606 sites per cell).
"
2.
Schizophrenia (Dementia Praecox)
05/07/2004 - "
There was a significant decrease in the density of [(125)I]iodosulpride in the pituitary (p < 0.001) and a strong trend to a decrease in binding in the caudate-putamen (p = 0.055) from subjects with schizophrenia.
"
05/07/2004 - "
There was a significant decrease in the Ki for haloperidol displaceable [(125)I]iodosulpride binding in the pituitary (p < 0.01) and caudate-putamen (p < 0.05) from subjects with schizophrenia with residual drugs in their tissue.
"
3.
Neuroblastoma
07/31/1989 - "
[125I] Iodosulpride binding was examined on eight human cell lines derived from lung, breast and digestive tract carcinomas, neuroblastomas and leukemia.
"
4.
Leukemia
07/31/1989 - "
[125I] Iodosulpride binding was examined on eight human cell lines derived from lung, breast and digestive tract carcinomas, neuroblastomas and leukemia.
"
5.
Carcinoma (Carcinomatosis)
07/31/1989 - "
[125I] Iodosulpride binding was examined on eight human cell lines derived from lung, breast and digestive tract carcinomas, neuroblastomas and leukemia.
"
Related Drugs and Biologics
1.
Haloperidol (Haldol)
2.
N-n-propylnorapomorphine