GDPmannose 4,6-dehydratase

09/15/2004 - "It was also shown that the FX enzyme regulated important interaction parameters between these cancer cells and endothelial cells. "
11/01/2001 - "Recently, we demonstrated that outside-in signaling regulates the expression of the FX enzyme in certain cancer cells. "
08/01/2013 - "The present study aimed to analyse the expression profiles of the FX enzyme and GDP-L-Fuc Tr in a cohort of operated CRC patients to elucidate their role in α(1,6)fucosylation in this neoplasm. "

04/28/2000 - "These results show that E48 controls the expression of the FX enzyme and of certain fucosylated E-selectin ligands by HNSCC. "
09/15/2004 - "In a previous study, we demonstrated that the fucose-generating FX enzyme regulates the expression of selectin ligands by B and T lymphocytes and by head and neck squamous cell carcinoma cells. "
04/20/2002 - "Head-and-neck squamous cell carcinoma (HNSCC) variants expressing high levels of E48, a human Ly-6 protein (E48(hi)), expressed higher levels of the fucose-generating FX enzyme and of the fucosylated E-selectin ligand sLe(a) than cells expressing low levels of E48 (E48(lo)). "

09/15/2004 - "The present study was aimed to determine whether the FX enzyme controls adhesive interactions between colorectal cancer cells and endothelial cells. "
09/15/2004 - "These results lead us to hypothesize that the FX enzyme controls the capacity of colorectal cancer to extravasate and form metastasis. "
08/01/2013 - "FX enzyme and GDP-L-Fuc transporter expression in colorectal cancer."
09/15/2004 - "These transfection experiments also indicated that manipulating the levels of the FX enzyme affected global cellular fucosylation and altered the interaction of colorectal cancer cells with some extracellular matrix components such as fibronectin. "
09/15/2004 - "Tumor-microenvironment interactions: the fucose-generating FX enzyme controls adhesive properties of colorectal cancer cells."

09/15/2004 - "If this hypothesis will be confirmed the FX enzyme could become a target molecule for metastasis prevention."
09/15/2004 - "These results lead us to hypothesize that the FX enzyme controls the capacity of colorectal cancer to extravasate and form metastasis. "

04/28/2000 - "By differential display we demonstrated that antibody-mediated ligation of the GPI-linked protein product of E48, a newly discovered human Ly-6 gene, up-regulates the expression of the FX enzyme in 3 lines of head and neck squamous carcinoma cells. "
04/28/2000 - "The GPI-linked Ly-6 antigen E48 regulates expression levels of the FX enzyme and of E-selectin ligands on head and neck squamous carcinoma cells."