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1,3- dichloro- 6- trifluoromethyl- 9- phenanthryl- 3- (n- butyl)aminopropanol
structure given in first source
Also Known As:
DCTFMP; desbutylhalofantrine; monodesbutylhalofantrine
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Polycyclic Aromatic Hydrocarbons: 2020
Phenanthrenes: 27
1,3-dichloro-6-trifluoromethyl-9-phenanthryl-3-(n-butyl)aminopropanol: 4
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Phenanthrenes: 27
1,3-dichloro-6-trifluoromethyl-9-phenanthryl-3-(n-butyl)aminopropanol: 4
Experts
1.
January, Craig T
: 1 article (09/2002)
2.
Mbai, Mackenzi
: 1 article (09/2002)
3.
Rajamani, Sridharan
: 1 article (09/2002)
Related Diseases
1.
Falciparum Malaria (Plasmodium falciparum Malaria)
01/01/1996 - "
Electrocardiographic changes and their relationship with profiles of halofantrine (H) and desbutylhalofantrine (DBH) were assessed in a prospective study of 34 male patients with an uncomplicated falciparum malaria.
"
01/01/1991 - "
The pharmacokinetics of halofantrine (HAL) and its principal metabolite, N-desbutylhalofantrine (BHAL), was investigated in 6 adult male patients of Melanesian origin with uncomplicated falciparum malaria.
"
01/01/1991 - "
Pharmacokinetics of halofantrine and n-desbutylhalofantrine in patients with falciparum malaria following a multiple dose regimen of halofantrine.
"
2.
Cardiotoxicity
09/01/2002 - "
Although N-desbutylhalofantrine has been suggested to be a safer antimalarial agent compared to halofantrine, our results suggest that the gain in the safety margin for QT interval prolongation-related cardiotoxicity is minimal.
"
3.
Malaria
03/01/1995 - "
1. Kenyan children with uncomplicated malaria given oral halofantrine (HF; non-micronised suspension; 8 mg base kg-1 body weight 6 hourly for three doses) showed wide variation in the disposition of HF and desbutylhalofantrine (HFm).
"
4.
Body Weight (Weight, Body)
03/01/1995 - "
1. Kenyan children with uncomplicated malaria given oral halofantrine (HF; non-micronised suspension; 8 mg base kg-1 body weight 6 hourly for three doses) showed wide variation in the disposition of HF and desbutylhalofantrine (HFm).
"
Related Drugs and Biologics
1.
halofantrine (Halfan)
2.
Suspensions
3.
Antimalarials (Antimalarial Agents)