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1,3- dichloro- 6- trifluoromethyl- 9- phenanthryl- 3- (n- butyl)aminopropanol

structure given in first source

Also Known As:

DCTFMP; desbutylhalofantrine; monodesbutylhalofantrine

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Phenanthrenes: 27
        1,3-dichloro-6-trifluoromethyl-9-phenanthryl-3-(n-butyl)aminopropanol: 4
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Phenanthrenes: 27
    - 1,3-dichloro-6-trifluoromethyl-9-phenanthryl-3-(n-butyl)aminopropanol: 4

Experts

1.	January, Craig T: 1 article (09/2002)
2.	Mbai, Mackenzi: 1 article (09/2002)
3.	Rajamani, Sridharan: 1 article (09/2002)

Related Diseases

1.	Falciparum Malaria (Plasmodium falciparum Malaria) 01/01/1996 - "Electrocardiographic changes and their relationship with profiles of halofantrine (H) and desbutylhalofantrine (DBH) were assessed in a prospective study of 34 male patients with an uncomplicated falciparum malaria. " 01/01/1991 - "The pharmacokinetics of halofantrine (HAL) and its principal metabolite, N-desbutylhalofantrine (BHAL), was investigated in 6 adult male patients of Melanesian origin with uncomplicated falciparum malaria. " 01/01/1991 - "Pharmacokinetics of halofantrine and n-desbutylhalofantrine in patients with falciparum malaria following a multiple dose regimen of halofantrine."
2.	Cardiotoxicity 09/01/2002 - "Although N-desbutylhalofantrine has been suggested to be a safer antimalarial agent compared to halofantrine, our results suggest that the gain in the safety margin for QT interval prolongation-related cardiotoxicity is minimal."
3.	Malaria 03/01/1995 - "1. Kenyan children with uncomplicated malaria given oral halofantrine (HF; non-micronised suspension; 8 mg base kg-1 body weight 6 hourly for three doses) showed wide variation in the disposition of HF and desbutylhalofantrine (HFm). "
4.	Body Weight (Weight, Body) 03/01/1995 - "1. Kenyan children with uncomplicated malaria given oral halofantrine (HF; non-micronised suspension; 8 mg base kg-1 body weight 6 hourly for three doses) showed wide variation in the disposition of HF and desbutylhalofantrine (HFm). "

Related Drugs and Biologics

1.	halofantrine (Halfan)
2.	Suspensions
3.	Antimalarials (Antimalarial Agents)