|1.||Brennan, T J: 1 article (06/2006)|
|2.||Pogatzki-Zahn, E M: 1 article (06/2006)|
|3.||Niemeier, J S: 1 article (06/2006)|
|4.||Sorkin, L S: 1 article (06/2006)|
|5.||Lippman, Jocelyn J: 1 article (03/2005)|
|6.||Jensen, Frances E: 1 article (03/2005)|
|7.||Levada, Rachel E: 1 article (03/2005)|
|8.||Sanchez, Russell M: 1 article (03/2005)|
|9.||Dai, Weimin: 1 article (03/2005)|
|10.||Ando, Hiroshi: 1 article (12/2004)|
06/01/2006 - "These findings indicate that JSTX influenced a spinal amplification process that leads to secondary hyperalgesia but does not contribute to primary hyperalgesia and guarding after incision. "
09/01/2003 - "Only secondary mechanical hyperalgesia was reversed by JSTX; primary mechanical hyperalgesia and guarding behavior were unchanged. "
11/26/1999 - "Rats receiving 3 microg JSTX 5 min or 6 h prior to burn showed no allodynia. "
06/01/2004 - "The allodynia induced by ACRO-A (500 ng x kg(-1)) was not inhibited by Joro spider toxin or NMDA receptor antagonists. "
06/01/2006 - "We further determined that only secondary mechanical hyperalgesia was reversed by JSTX, a selective antagonist of calcium-permeable AMPA receptor; primary mechanical hyperalgesia and guarding behavior were unchanged. "
01/08/1996 - "The anticonvulsant effect of 1-naphthylacetyl spermine (1-NA-Spm), an analogue of Joro spider toxin, against amygdaloid kindled seizures was studied in rats. "
01/08/1996 - "Potent and long-lasting anticonvulsant effects of 1-naphthylacetyl spermine, an analogue of Joro spider toxin, against amygdaloid kindled seizures in rats."
05/22/1992 - "The pretreatment with JSTX analogue significantly inhibited both of QUIS-induced hippocampal discharges (80-11%) and generalized tonic clonic seizures (100-33%) in a dose-dependent manner, whereas JSTX had no effect on seizures induced by quinolinate, a NMDA agonist. "
03/30/2005 - "CaN activation appears to be dependent on seizure-induced activation of Ca2+-permeable AMPA receptors (AMPARs), because the upregulation of CaN activation and GABA(A)R inhibition were attenuated by GYKI 52466 [1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride] or Joro spider toxin. "
05/22/1992 - "The anticonvulsant effect of 1-naphthylacetyl spermine, an analogue of Joro spider toxin (JSTX), was studied against seizures induced by quisqualate (QUIS), a non-NMDA agonist, as assessed electrophysiologically and behaviorally in freely moving rats. "
|3.||Ganglion Cysts (Ganglion)
12/01/2004 - "Joro-spider toxin (JSTX) blocked myocardial excitatory junctional potentials evoked by the cardiac ganglion. "
03/15/2000 - "3. The results indicate that the AMPA receptors of the cochlear ganglion, nucleus magnocellularis and nucleus laminaris share a number of structural and functional properties that distinguish them from the AMPA receptors of brainstem motor neurons, namely a lower relative abundance of glutamate receptor (GluR)2 transcript and much lower levels of GluR2 immunoreactivity, higher relative levels of GluR3 flop and GluR4 flop, lower relative abundance of the C-terminal splice variants GluR4c and 4d, less R/G editing of GluR2 and 3, greater permeability to calcium, predominantly inwardly rectifying I-V relationships, and greater susceptibility to block by Joro spider toxin. "
07/01/1995 - "5. Because the EPSCs in CA1 neurons after ischemia are mediated by Ca(2+)-permeable non-NMDA receptor-mediated conductances, the present results indicate that Naspm and JSTX are effective at blocking abnormal EPSCs that may induce Ca2+ accumulation leading to delayed neuronal death after transient ischemic insult."
|1.||AMPA Receptors (AMPA Receptor)
|2.||JSTX spider toxin
|6.||Glutamate Receptors (Glutamate Receptor)
|9.||gamma-Aminobutyric Acid (GABA)