AH 21-132

Also Known As:

6-(4-acetamidophenyl)-1,2,3,4,4a,10b-hexahydro-8,9-dimethoxy-2-methylbenzo(c)(1,6)-naphthyridine-bis(hydrogen maleate); AH 21132; AH-21-132; Acetamide, N-(4-(1,2,3,4,4a,10b-hexahydro-8,9-dimethoxy-2-methylbenzo(c)(1,6)naphthyridin-6-yl)phenyl)-, cis-, (Z)-2-butenedioate (1:2)

Networked: 7 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Naphthyridines: 2
      - AH 21-132: 7

Related Diseases

1.	Asthma (Bronchial Asthma) 08/01/1989 - "1. AH 21-132 is being investigated as a potential chemotherapeutic agent for bronchial asthma. " 02/01/1995 - "These results suggest that AH 21-132 has an anti-allergic effect in the airway and that these actions may be beneficial for the treatment of allergic bronchial asthma."
2.	Spasm (Spasms) 01/01/1991 - "Unlike theophylline, AH 21-132 does not cause spasm of cooled (12 degrees C), indomethacin-treated trachealis muscle, nor does it act as an antagonist at adenosine A1 receptors. " 08/01/1989 - "However, AH 21-132 can be differentiated from theophylline in that: (a) its relaxant potency is increased by epithelial removal; (b) it does not cause tracheal spasm; (c) it exhibits selectivity as an inhibitor of cyclic AMP-dependent as opposed to cyclic GMP-dependent phosphodiesterase. "
3.	Respiratory Hypersensitivity 05/01/1991 - "[The effect of AH 21-132 on airway hyperresponsiveness induced by ozone exposure]." 05/01/1991 - "We examined the effect of AH 21-132, which has been reported to relax airway smooth muscle and inhibit platelet activating factor (PAF)-induced airway hyperreactivity, on ozone-induced airway hyperresponsiveness (AHR) with airway inflammation in dogs. "
4.	Pulmonary Eosinophilia (Eosinophilic Pneumonia) 01/01/1990 - "Human recombinant lymphokines and cytokines induce pulmonary eosinophilia in the guinea pig which is inhibited by ketotifen and AH 21-132."
5.	Inflammation (Inflammations) 05/01/1991 - "We examined the effect of AH 21-132, which has been reported to relax airway smooth muscle and inhibit platelet activating factor (PAF)-induced airway hyperreactivity, on ozone-induced airway hyperresponsiveness (AHR) with airway inflammation in dogs. "

Related Drugs and Biologics

1.	Anti-Allergic Agents (Antiallergic Agents)
2.	Theophylline (Theon)
3.	Phosphoric Diester Hydrolases (Phosphodiesterases)
4.	Ketotifen (Ketotifene)
5.	Aminophylline (Carine)
6.	Adenosine A1 Receptor
7.	Rolipram
8.	Cytokines
9.	Platelet Activating Factor
10.	Ozone