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4-(N-nitroso-N-methylamino)butyric acid
Also Known As:
NNMAB; nitrosomethyl-3-carboxypropylamine
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Nitroso Compounds: 446
Nitrosamines: 1539
4-(N-nitroso-N-methylamino)butyric acid: 2
Related Diseases
1.
Neoplasms (Cancer)
03/01/1988 - "
Nitrosomethyl-3-carboxypropylamine at 75 mg/ml and a total dose of 6.2 mmol per rat induced a high incidence of bladder tumors and tumors of the kidney pelvis, but not tumors of the nasal mucosa; the median week of death for this group was 55 weeks.
"
01/30/1998 - "
To investigate the two activities, brief treatments of male F344 rats with each of three mutagens, nitrosodimethylurea, nitrosodiethylurea and nitrosobis-(2-oxopropyl)-amine, were followed by chronic treatment (40 weeks) with one of four non-mutagens, nitrosomethyl-3-carboxypropylamine, nitrosodiethanolamine, nitrosomethyl-2-hydroxypropylamine or phenobarbital, the last being a well-known promotor of liver tumors in rats.
"
2.
Urinary Bladder Neoplasms (Bladder Cancer)
03/01/1988 - "
Nitrosomethyl-3-carboxypropylamine at 75 mg/ml and a total dose of 6.2 mmol per rat induced a high incidence of bladder tumors and tumors of the kidney pelvis, but not tumors of the nasal mucosa; the median week of death for this group was 55 weeks.
"
03/01/1988 - "
It is concluded that nitrosomethyl-n-alkylamines that induce bladder tumors by oral administration to rats are metabolized to nitrosomethyl-3-carboxypropylamine, which is excreted in the urine and further metabolized to nitrosomethyl-2-oxopropylamine, the proximate bladder carcinogen.
"
Related Drugs and Biologics
1.
Phenobarbital (Luminal)
2.
Mutagens
3.
Carcinogens
4.
1,3-diethyl-1-nitrosourea
5.
N,N'-dimethylnitrosourea
Related Therapies and Procedures
1.
Oral Administration