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4-(N-nitroso-N-methylamino)butyric acid

Also Known As:

NNMAB; nitrosomethyl-3-carboxypropylamine

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Nitroso Compounds: 446
  - Nitrosamines: 1539
    - 4-(N-nitroso-N-methylamino)butyric acid: 2

Related Diseases

1.	Neoplasms (Cancer) 03/01/1988 - "Nitrosomethyl-3-carboxypropylamine at 75 mg/ml and a total dose of 6.2 mmol per rat induced a high incidence of bladder tumors and tumors of the kidney pelvis, but not tumors of the nasal mucosa; the median week of death for this group was 55 weeks. " 01/30/1998 - "To investigate the two activities, brief treatments of male F344 rats with each of three mutagens, nitrosodimethylurea, nitrosodiethylurea and nitrosobis-(2-oxopropyl)-amine, were followed by chronic treatment (40 weeks) with one of four non-mutagens, nitrosomethyl-3-carboxypropylamine, nitrosodiethanolamine, nitrosomethyl-2-hydroxypropylamine or phenobarbital, the last being a well-known promotor of liver tumors in rats. "
2.	Urinary Bladder Neoplasms (Bladder Cancer) 03/01/1988 - "Nitrosomethyl-3-carboxypropylamine at 75 mg/ml and a total dose of 6.2 mmol per rat induced a high incidence of bladder tumors and tumors of the kidney pelvis, but not tumors of the nasal mucosa; the median week of death for this group was 55 weeks. " 03/01/1988 - "It is concluded that nitrosomethyl-n-alkylamines that induce bladder tumors by oral administration to rats are metabolized to nitrosomethyl-3-carboxypropylamine, which is excreted in the urine and further metabolized to nitrosomethyl-2-oxopropylamine, the proximate bladder carcinogen."

Related Drugs and Biologics

1.	Phenobarbital (Luminal)
2.	Mutagens
3.	Carcinogens
4.	1,3-diethyl-1-nitrosourea
5.	N,N'-dimethylnitrosourea

Related Therapies and Procedures

1.	Oral Administration