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melarsen oxide

inhibits glutathione reductase

Also Known As:

melarsenoxide; p-(4,6-diamino-1,3,5-triazin-2-yl)aminophenylarsonous acid

Networked: 10 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Abdeen, Ziad: 1 article (12/2010)
2.	Azmi, Kifaya: 1 article (12/2010)
3.	Baneth, Gad: 1 article (12/2010)
4.	Berlin, Dalia: 1 article (12/2010)
5.	Ereqat, Suheir: 1 article (12/2010)
6.	Nasereddin, Abedelmajeed: 1 article (12/2010)
7.	Alibu, Vincent P: 1 article (03/2006)
8.	Brun, Reto: 1 article (03/2006)
9.	Clayton, Christine: 1 article (03/2006)
10.	Marti, Gabriela: 1 article (03/2006)

Related Diseases

1.	Infections 12/01/1958 - "rhodesiense infections in mice were compared: the CD50 for compound 12,065 was 6.5 mg./kg. and for melarsen oxide/BAL was 3.7 mg./kg. The ratios LD50/CD50 for the drugs were about 4 and 6 respectively." 03/01/1994 - "Combinations of DL-alpha-difluoromethylornithine (DFMO; eflornithine; Ornidyl) with either suramin or melarsen oxide were found to be effective against acute laboratory model infections with Trypanosoma brucei rhodesiense. " 09/01/1993 - "evansi infections by the introduction of a new arsenic compound, melarsenoxide cysteamine, chemotherapy of T. " 03/01/1994 - "An infection with a melarsen oxide-refractory isolate was cured by a combination of low-dose DFMO (0.5% in the drinking water) plus low-dose suramin (1 mg/kg of body weight given intraperitoneally). "
2.	Trypanosomiasis 12/01/1948 - "Melarsen oxide in the treatment of human trypanosomiasis." 05/01/1992 - "A comparison was made between the efficacy of mel Cy (Cymelarsan) and melarsen oxide to cure central nervous system trypanosomiasis in a chronic Trypanosoma brucei mouse model. " 05/01/1992 - "Relative efficacy of melarsen oxide compared with mel Cy (Cymelarsan) when used in combination with difluoromethylornithine in the treatment of trypanosomiasis of the central nervous system."
3.	Body Weight (Weight, Body) 03/01/1994 - "An infection with a melarsen oxide-refractory isolate was cured by a combination of low-dose DFMO (0.5% in the drinking water) plus low-dose suramin (1 mg/kg of body weight given intraperitoneally). "
4.	Parasitemia 12/15/2010 - "An anaphylactic-like reaction, fatal in one case, was observed in 2 camels diagnosed with severe trypanosome parasitemia immediately following treatment with melarsenoxide cysteamine. "
5.	African Trypanosomiasis (Nagana) 09/01/1946 - "The treatment of African sleeping sickness with two new trivalent arsenical preparations (melarsen oxide and 70A)."

Related Drugs and Biologics

1.	Eflornithine (Ornidyl)
2.	Drinking Water
3.	Suramin (Suramin Sodium)
4.	melaminylthioarsenate
5.	Cysteamine (Mercaptamine)
6.	Melarsoprol (Mel B)
7.	Arsenic

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)