metaphit

03/22/2005 - "Ontogenetic study of metaphit-induced audiogenic seizures in rats."
11/01/2007 - "injected either alone or in combination to adult Wistar male rats with fully developed metaphit seizures after eight audiogenic testing. "
10/01/2007 - "into rats with fully developed metaphit seizures after the eighth audiogenic testing. "
01/01/2006 - "Metaphit-treated rats displaying seizures in 8 previous tests were i.p. "
06/01/2005 - "Severity of metaphit seizures increased with time to reach the peak 7-12 h after injection. "

03/01/2002 - "The effects of delta sleep-inducing peptide on incidence and severity in metaphit-induced epilepsy in rats."
05/01/2001 - "[The delta-sleep inducing peptide and its effect on the electroencephalogram and power spectrum density in rats with metaphit-induced epilepsy]."
01/01/1999 - "The influence of APV ((+/-)-2-amino-5-phosphonovaleric acid) on EEG activity and behavior was studied on a model of epilepsy induced by intraperitoneal administration of metaphit (1-(1-(3-isothiocyanatophenyl)-cyclohexyl)-piperidine). "
11/01/2007 - "Taken together, the results of the present study suggest that the combinations of valproate and DSIP should be considered as beneficial polytherapy in metaphit model of epilepsy."
05/01/2001 - "Metaphit induces a generalized, reflex epilepsy thus providing an experimental model of choice for the studies of the mechanism of epilepsy development and blockade of NMDA/PCP receptors. "

09/01/2000 - "[Potentiation of metaphit-induced audiogenic epilepsy with N-methyl-D-aspartate in rats]."
05/01/2001 - "The effects of a natural somnogenic nonapeptide DSIP on metaphit-induced audiogenic epilepsy in rats were studied with the aim of shedding more light on answering the question whether DSIP could be included in the list of antiepileptic agents. "
10/01/2007 - "We investigated the effects of hypothermia on the incidence and EEG signs of audiogenic seizures in rats treated with metaphit (1-[1(3isothiocyanatophenyl)-cyclohexyl] piperidine), an experimental model of generalized reflex epilepsy. "
05/01/2001 - "Metaphit induces a generalized, reflex epilepsy thus providing an experimental model of choice for the studies of the mechanism of epilepsy development and blockade of NMDA/PCP receptors. "
10/01/2007 - "1. The blocking effects of valproate (2-propylpentanoic acid), a standard anti-epileptic drug, on metaphit (1-[1-(3-isothiocyanatophenyl)-cyclohexyl]-piperidine)-induced audiogenic seizures as a model of generalized, reflex audiogenic epilepsy in adult Wistar male rats were studied. "

09/01/1985 - "PCP-induced catalepsy in pigeons, which is a pharmacologically specific and stereoselective phenomenon, was used to study pharmacological consequences of the proposed covalent bonding of metaphit to PCP sites. "
05/01/1986 - "In pigeons, metaphit induced PCP-like catalepsy after i.c.v. administration and, after i.m. "
09/01/1985 - "Isobolographic analysis of the interactions between metaphit and PCP-like drugs suggested that metaphit potentiated the catalepsy-inducing effects of these drugs. "
09/01/1985 - "Metaphit itself induced a PCP-like catalepsy. "
09/01/1985 - "Effects of metaphit, a proposed phencyclidine receptor acylator, on catalepsy in pigeons."

06/01/2005 - "Previous studies have shown that humoral, endogenous and somnogenic, delta sleep-inducing peptide (DSIP) has influence on insomnia, pain, adaptation to stress, epilepsy, etc. We investigated the potential of DSIP and its analogue DSIP-12 (a nonapeptide with alanine in position 2 of DSIP molecule substituted by beta-alanine) to antagonize metaphit (1-[1(3-isothiocyanatophenyl)-cyclohexyl]piperidine) induced generalized, reflex audiogenic seizures in adult male Wistar albino rats. "