LY 171883

structure in first source; leukotriene receptor antagonist

Also Known As:

1-((2-hydroxy-3-propyl)-4-(1H-tetrazol-5-yl)butoxyphenyl)ethanone; LY-171883; LY171883; Lilly 171883; Ethanone, 1-(2-hydroxy-3-propyl-4-(4-(1H-tetrazol-5-yl)butoxy)phenyl)-

Networked: 36 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Ketones: 2618
  - Acetophenones: 16
    - LY 171883: 36
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Tetrazoles: 14
      - LY 171883: 36

Experts

1.	Kim, Hyun Chang: 1 article (10/2009)
2.	Kim, Seong Deok: 1 article (10/2009)
3.	Lee, Ji Won: 1 article (10/2009)
4.	Rho, Ji Yoon: 1 article (10/2009)
5.	Shin, Hwa Yong: 1 article (10/2009)
6.	Huang, Hung-Tu: 1 article (08/2002)
7.	Li, Ping-Chia: 1 article (08/2002)
8.	Liang, Jin-Tung: 1 article (08/2002)
9.	Lin, Pei-Hsuan: 1 article (08/2002)
10.	Wu, Sheng-Nan: 1 article (08/2002)

Related Diseases

1.	Weight Gain 11/01/1990 - "Posttreatment with 5,8,11,14-eicosatetraynoic acid (ETYA), a nonmetabolized competitive inhibitor of arachidonic acid metabolism, or the leukotriene receptor blockers, FPL 55712 and LY 171883, also dramatically reduced the lung weight gain caused by phosgene. "
2.	Hyperinsulinism (Hyperinsulinemia) 10/01/1989 - "In characterizing this putative central mechanism for the regulation of pancreatic insulin secretion, hyperinsulinemia and fever elicited by IL-1 injected intravenously (iv) or intracerebroventricularly (icv) was totally eliminated by prior cyclooxygenase inhibition with indomethacin, ibuprofen, or meclofenamate but not lipoxygenase inhibition with propyl gallate or leukotriene receptor antagonism with LY 171883. "
3.	Fever (Fevers) 10/01/1989 - "In characterizing this putative central mechanism for the regulation of pancreatic insulin secretion, hyperinsulinemia and fever elicited by IL-1 injected intravenously (iv) or intracerebroventricularly (icv) was totally eliminated by prior cyclooxygenase inhibition with indomethacin, ibuprofen, or meclofenamate but not lipoxygenase inhibition with propyl gallate or leukotriene receptor antagonism with LY 171883. "
4.	Shock 07/01/1990 - "LY171883 preserves mesenteric perfusion in porcine endotoxic shock." 02/01/1995 - "Circulatory shock was induced by acute hemorrhage to a mean arterial pressure (MAP) of 45 mm Hg. We investigated the effect of SQ-29,548 and LY-171883 on the progression of circulatory shock. " 11/01/1990 - "In the present study, the effects of a selective LTD4/E4 receptor antagonist, LY171883 (LY), or a selective LTD4 receptor antagonist, SKF-104353 (SKF), were assessed on splanchnic and pulmonary localization of 99mTechnetium-labeled human serum albumin (99mTc-HSA) in acute endotoxic shock in the rat. "
5.	Septic Shock (Toxic Shock Syndrome) 01/01/1987 - "In this study the effect of LY171883, a selective leukotriene D4/E4 antagonist, on the hemodynamic alterations of endotoxin shock was assessed. "

Related Drugs and Biologics

1.	Leukotriene Receptors (Leukotriene Receptor)
2.	Indomethacin (Indometacin)
3.	Lipoxygenase (Lipoxygenase-1)
4.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
5.	Arachidonic Acid (Vitamin F)
6.	5,8,11,14-Eicosatetraynoic Acid (5,8,11,14 Eicosatetraynoic Acid)
7.	Propyl Gallate
8.	Phosgene
9.	Meclofenamic Acid (Meclofenamate)
10.	Interleukin-1 (Interleukin 1)

Related Therapies and Procedures

1.	Fat-Restricted Diet (Diet, Fat Restricted)