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LY 165163 (PAPP)

structure given in first source; a serotonin agonist
Also Known As:
PAPP; 1-(2-(4-aminophenyl)ethyl)-4-(3-trifluoromethylphenyl)piperazine; LY 165163, hydrochloride; LY-165163; p-NH2-PE-TFMPP
Networked: 73 relevant articles (3 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Bilchick, Kenneth C: 3 articles (09/2021 - 12/2016)
2. Kennedy, Jamie L W: 3 articles (09/2021 - 12/2016)
3. Mazimba, Sula: 3 articles (09/2021 - 12/2016)
4. Hayasaka, Riku: 2 articles (08/2022 - 10/2021)
5. Kamiya, Yusuke: 2 articles (08/2022 - 10/2021)
6. Yamazaki, Hiroshi: 2 articles (08/2022 - 10/2021)
7. Kwon, Younghoon: 2 articles (09/2021 - 11/2017)
8. Mihalek, Andrew: 2 articles (09/2021 - 11/2017)
9. Mwansa, Hunter: 2 articles (09/2021 - 11/2017)
10. Parker, Alex M: 2 articles (09/2021 - 11/2017)

Related Diseases

1. Psoriasis (Pustulosis Palmaris et Plantaris)
10/01/2012 - "In these phase II, multicentre, randomized, double-blind, placebo-controlled, dose-ranging studies, 198 patients with severe chronic plaque-type psoriasis [Psoriasis Area and Severity Index (PASI) ≥ 12, body surface area (BSA) ≥ 10] were enrolled in Papp et al. between December 2009 and April 2010 and 142 patients in Leonardi et al. between April 2010 and March 2011. "
10/01/2012 - "Additionally in Papp et al. the BSA and Medical Outcomes Study 36-item short-form health survey, and in Leonardi et al. the joint pain visual analogue scale (VAS), itch severity VAS, Nail Psoriasis Severity Index (NAPSI) and the Psoriasis Scalp Severity Index (PSSI) were also measured. "
10/01/2012 - "Papp et al. and Leonardi et al. concluded that brodalumab and ixekizumab, respectively, significantly improved plaque psoriasis in 12-week, phase II studies. "
11/17/2020 - "Lebwohl MG, Papp KA, Stein Gold L, et al. Trial of roflumilast cream for chronic plaque psoriasis. "
10/01/2012 - "STUDY EXPOSURE: In Papp et al., patients with chronic plaque-type psoriasis were randomly assigned to receive placebo or brodalumab at a dose of 70, 140 or 210 mg, administered subcutaneously on day 1 and at weeks 1, 2, 4, 6, 8 and 10, or at a dose of 280 mg administered subcutaneously on day 1 and at weeks 4 and 8. In Leonardi et al., patients were randomly assigned to receive subcutaneous injections of placebo or 10, 25, 75 or 150 mg of ixekizumab at 0, 2, 4, 8, 12 and 16 weeks, followed by a 4-week follow-up period. "
2. Arteriovenous Fistula
3. Poisoning
4. Down Syndrome (Down's Syndrome)
5. Breast Neoplasms (Breast Cancer)
09/01/2001 - "The discovery of the PAPP-E variants will help in the deciphering of the physiology of this new family of metzincins in not only the placenta during pregnancy but also the mammary gland in breast cancer. "
08/01/2022 - "The present study aimed to investigate the relationship between in silico-generated Papp (from apical to basal side, Papp A to B) for 301 substances with diverse structures and a binary classification of the reported roles of efflux P-glycoprotein or breast cancer resistant protein. "
06/01/2021 - "It was thus applied to investigate the characteristics of TIL across various intestinal regions and the interaction between TIL and adenosine triphosphate (ATP)-binding cassette family proteins (ABC) including, P-glycoprotein (P-gp), multidrug resistance-associated protein 2 (MRP2), and breast cancer resistance protein (BCRP).The data of the bi-directional transport showed that the ileum had the higher apparent permeability coefficient (Papp) of TIL than duodenum and jejunum, suggesting the best absorption of TIL in the ileum.In"
09/10/2020 - "Experiments using known substrates of peptide transporter 1 (PEPT1), organic anion transporting polypeptide (OATP2B1), organic cation transporter 1 (OCT1), P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), multi drug resistance-associated protein 2 and 3 (MRP2 and MRP3), in the absence and presence of potent inhibitors, showed that there was a statistically significant change in apparent intestinal permeability Papp,pig (cm/s) in the presence of the corresponding inhibitor. "

Related Drugs and Biologics

1. brodalumab
2. ixekizumab
3. Cyanides (Isocyanides)
4. Proteins (Proteins, Gene)
5. Pregnancy-Associated Plasma Protein-A (PAPP-A)
6. Member 1 Subfamily B ATP Binding Cassette Transporter
7. Messenger RNA (mRNA)
8. Blood Proteins (Serum Proteins)
9. Stem Cell Factor
10. FSH Receptors (FSH Receptor)

Related Therapies and Procedures

1. Subcutaneous Injections
2. Transplantation
3. Prenatal Care (Care, Prenatal)
4. Patient Readmission
5. Heart-Assist Devices