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Sch 34343
structure given in first source; RN given refers to (5R-(5alpha,6alpha))-isomer
Also Known As:
2-carbamoyloxyethylthio-6-(1-hydroxyethyl)penem-3-carboxylic acid; Sch-34343
Networked:
9
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amides: 2428
Lactams: 2198
Sch 34343: 9
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Lactams: 2198
Sch 34343: 9
Related Diseases
1.
Infections
06/01/1985 - "
On the basis of these promising results, Sch 34343 merits further in-vitro and in-vivo study to define its potential usefulness in treatment of infections with these pathogens in humans.
"
06/01/1985 - "
We concluded that Sch 34343 is a highly promising agent with a broad spectrum of activity making it potentially suitable as monotherapy for patients with infection of undetermined bacterial aetiology, particularly if Bact.
"
06/01/1985 - "
Sch 34343 is a promising agent for the treatment of anaerobic infections because it can penetrate into anaerobic abscesses and can kill large numbers of bacteria within abscesses.
"
06/01/1985 - "
On the basis of its activity in vitro, Sch 34343 appears to be one of the most promising new antimicrobial agents for the treatment of infections involving anaerobic bacteria.
"
06/01/1985 - "
Based on these results, Sch 34343 appears to be a promising antimicrobial agent for anaerobic infections and warrants further clinical investigations.
"
2.
Neoplasms (Cancer)
08/01/1986 - "
In-vitro activity of Sch 34343, a new penam, against gram-positive isolates from cancer patients.
"
01/01/1986 - "
In vitro activity of SCH-34343, a new penam, and other antimicrobial agents against clinical isolates from cancer patients.
"
01/01/1986 - "
The in vitro activity of SCH-34343, a new penam antibiotic, was tested against gram-positive and gram-negative isolates from cancer patients, and compared to that of 7 other antimicrobial agents.
"
08/01/1986 - "
The in-vitro activity of Sch 34343, a new penam antibiotic, was tested against 257 Gram-positive isolates from cancer patients, and compared with that of imipenem and amifloxacin.
"
3.
Abscess
06/01/1985 - "
Within 1 h after injection of Sch 34343, the drug was present in higher concentrations in the abscesses than in the blood of infected animals.
"
06/01/1985 - "
In-vivo bactericidal activity of Sch 34343 in Bacteroides fragilis abscesses and in Bacteroides fragilis-Escherichia coli abscesses.
"
06/01/1985 - "
After five days of Sch 34343 therapy with either 100 or 400 mg/kg administered five times a day to mice with subcutaneous abscesses, the numbers of Bact.
"
06/01/1985 - "
Sch 34343 is a promising agent for the treatment of anaerobic infections because it can penetrate into anaerobic abscesses and can kill large numbers of bacteria within abscesses.
"
06/01/1985 - "
In an anaerobic abscess model in mice, Sch 34343 was more active than cefoxitin and clindamycin against Bacteroides fragilis.
"
4.
Body Weight (Weight, Body)
06/01/1985 - "
Pharmacokinetic parameters of Sch 34343 have been determined for mice, rats, rabbits, monkeys, dogs and humans and correlated among species as an exponential function of body weight.
"
Related Drugs and Biologics
1.
Anti-Infective Agents (Microbicides)
2.
Anti-Bacterial Agents (Antibiotics)
3.
Imipenem
4.
Moxalactam (Latamoxef)
5.
Clindamycin (Cleocin)
6.
Cephalothin (Cefalotin)
7.
Cefoxitin (Cefoxitin Sodium)
8.
Cefotaxime (Kendrick)
9.
Cefamandole
10.
amifloxacin
Related Therapies and Procedures
1.
Therapeutics