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vindeburnol

eburnamine derivative; RN given refers to (3alpha,14beta)-(+) isomer; structure given in first source

Also Known As:

RU 24722; RU-24722

Networked: 6 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Braun, David: 2 articles (01/2019 - 04/2012)
2.	Feinstein, Douglas L: 2 articles (01/2019 - 04/2012)
3.	Kalinin, Sergey: 1 article (04/2012)
4.	Lin, Shao X: 1 article (04/2012)
5.	Polak, Paul E: 1 article (04/2012)
6.	Sharp, Anthony: 1 article (04/2012)

Related Diseases

1.	Brain Ischemia (Cerebral Ischemia) 01/01/1985 - "The influence of a new eburnamenine derivative RU 24722 [(3 beta, 14 alpha, 16 alpha)-(+/-)-14,15-dihydro-20,21-dinoreburnamenin -14-ol] on post-ischemic EEG recovery was studied in N2O anesthetized rats subjected to 1 min of global-compression cerebral ischemia. " 10/01/1986 - "Vindeburnol at 2 mg/kg i.v., increased the EEG resistance time in rats subjected to asphyxia anoxia and at 10 mg/kg s.c., significantly improved the electrocortical recovery of gerbils subjected to a 10-min cerebral ischemia. "
2.	Asphyxia (Suffocation) 10/01/1986 - "Vindeburnol at 2 mg/kg i.v., increased the EEG resistance time in rats subjected to asphyxia anoxia and at 10 mg/kg s.c., significantly improved the electrocortical recovery of gerbils subjected to a 10-min cerebral ischemia. "
3.	Hypoxia (Hypoxemia) 10/01/1986 - "Vindeburnol at 2 mg/kg i.v., increased the EEG resistance time in rats subjected to asphyxia anoxia and at 10 mg/kg s.c., significantly improved the electrocortical recovery of gerbils subjected to a 10-min cerebral ischemia. "
4.	Ischemia 01/01/1985 - "Effects of the new eburnamenine derivative RU 24722 on EEG recovery and cerebral energy metabolism after complete ischemia." 01/01/1985 - "In an attempt to elucidate its mechanism of action, the influence of RU 24722 on changes in the cerebral metabolic energy reserves was studied in mouse brain after different periods of decapitation ischemia. " 01/01/1985 - "RU 24722, a compound selected for its protective effect against cerebral anoxia and ischemia in rats, induced a dose-dependent increase in brain ornithine decarboxylase (ODC), a rate limiting enzyme in the biosynthesis of polyamines. " 10/01/1986 - "Vindeburnol (10 mg/kg i.p.) significantly retarded glucose, phosphocreatine and adenosine triphosphate utilization and lactate production in mouse brain during 10 s of decapitation ischemia. "
5.	Decapitation 01/01/1985 - "In an attempt to elucidate its mechanism of action, the influence of RU 24722 on changes in the cerebral metabolic energy reserves was studied in mouse brain after different periods of decapitation ischemia. " 10/01/1986 - "Vindeburnol (10 mg/kg i.p.) significantly retarded glucose, phosphocreatine and adenosine triphosphate utilization and lactate production in mouse brain during 10 s of decapitation ischemia. "

Related Drugs and Biologics

1.	Dihydrotachysterol (AT 10)
2.	Vincamine
3.	Lactic Acid (Lactate)
4.	Neuroprotective Agents
5.	Yohimbine (Yocon)
6.	Serotonin (5 Hydroxytryptamine)
7.	Polyamines
8.	Phosphocreatine (Neoton)
9.	Ornithine Decarboxylase (Decarboxylase, Ornithine)
10.	Morphine (MS Contin)