|1.||Lütjohann, D: 13 articles (04/2014 - 06/2000)|
|2.||Leoni, Valerio: 10 articles (04/2014 - 10/2002)|
|3.||Björkhem, Ingemar: 8 articles (10/2013 - 10/2002)|
|4.||von Bergmann, K: 8 articles (02/2006 - 06/2000)|
|5.||Lütjohann, Dieter: 7 articles (08/2010 - 02/2002)|
|6.||Heun, R: 7 articles (02/2006 - 06/2000)|
|7.||Acar, Niyazi: 5 articles (11/2012 - 03/2007)|
|8.||Creuzot-Garcher, Catherine: 5 articles (11/2012 - 03/2007)|
|9.||Bretillon, Lionel: 5 articles (11/2012 - 03/2007)|
|10.||Bron, Alain: 5 articles (11/2012 - 03/2007)|
02/06/1999 - "The neurotoxic effect of 24-hydroxycholesterol on SH-SY5Y human neuroblastoma cells."
09/06/2012 - "Protective effects of 27- and 24-hydroxycholesterol against staurosporine-induced cell death in undifferentiated neuroblastoma SH-SY5Y cells."
09/06/2012 - "In the current study we examined the effects of 27- and 24-hydroxycholesterol on viability of human neuroblastoma SH-SY5Y cells treated with staurosporine, a toxic substance that induces apoptosis. "
01/01/2009 - "Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells."
12/01/2008 - "Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and alpha-synuclein in human neuroblastoma SH-SY5Y cells."
|2.||Alzheimer Disease (Alzheimer's Disease)
06/21/2005 - "In this study, we examined the effects of 24S-hydroxycholesterol on gene expression in human neural cells, a primary coculture of neurons and glia useful for studying pathogenic mechanisms in Alzheimer's disease. "
10/02/2009 - "Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease."
05/01/2006 - "Polymorphism in ABCA1 influences CSF 24S-hydroxycholesterol levels but is not a major risk factor of Alzheimer's disease."
06/21/2005 - "While the concentration of this neurotoxic oxysterol decreases with age, 24S-hydroxycholesterol is elevated in Alzheimer's disease. "
09/01/2003 - "Concentrations of 24S-hydroxycholesterol in plasma and cerebrospinal fluid (CSF) are significantly higher in Alzheimer's disease and vascular demented patients at early stages of the disease compared to healthy subjects. "
|3.||Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy)
01/01/2011 - "Plasma 24S-hydroxycholesterol levels in elderly subjects with late onset Alzheimer's disease or vascular dementia: a case-control study."
09/01/2004 - "Recent studies have shown elevated plasma concentrations of 24-hydroxycholesterol in patients with AD and vascular dementia, suggesting increased brain cholesterol turnover during neurodegeneration. "
09/30/2004 - "Alterations in brain cholesterol metabolism and reduced 24S-hydroxycholesterol plasma levels have been described in Alzheimer's disease (AD) and vascular dementia (VD). "
06/26/2000 - "Recent findings suggest that plasma 24S-hydroxycholesterol may be elevated in Alzheimer's disease (AD) and vascular dementia at least at some stage of the disease, suggesting increased brain cholesterol turnover during neurodegeneration. "
02/01/2002 - "Previous studies have shown that patients with early onset of Alzheimer disease and vascular dementia have higher levels of circulating brain-derived 24S-hydroxycholesterol (cerebrosterol). "
11/01/2012 - "Our previous studies suggested that CYP46A1 and 24S-hydroxycholesterol (24SOH) may be associated with glaucoma. "
09/01/2011 - "These data suggest the potential involvement of CYP46A1 and 24S-hydroxycholesterol in the pathophysiology of glaucoma."
09/01/2011 - "24S-hydroxycholesterol and cholesterol-24S-hydroxylase (CYP46A1) in the retina: from cholesterol homeostasis to pathophysiology of glaucoma."
04/01/2007 - "Based on the link between cholesterol-24S-hydroxylase, 24S-hydroxycholesterol, and neurologic disorders, CYP46A1 may be a valuable gene candidate for retinal pathologies like age-related macular degeneration or glaucomas, and 24S-hydroxycholesterol may be involved in the onset of the degenerative processes in these diseases."
07/01/2006 - "In this study, we related plasma cerebrosterol concentrations in 46 MS patients - 27 with a relapsing-remitting (RR) disease course and 19 with a primary progressive (PP) course - to three conventional magnetic resonance imaging measures: on T(1)-weighted brain scans, volume of gadolinium-enhanced lesions (a marker of active inflammation) and hypointense lesions (a marker of edema or axonal loss) and on T(2)-weighted scans, volume of hyperintense lesions (a marker of disease extent). "
03/01/2007 - "We conclude that in confluent primary porcine RPE cells, 24-hydroxycholesterol, 25-hydroxycholesterol, and 7-ketocholesterol are potent inducers of oxidation and inflammation."
|3.||cholesterol 24-hydroxylase (CYP46)
|6.||Amyloid (Amyloid Fibrils)
|7.||Apolipoproteins E (ApoE)
|8.||Cyclooxygenase 2 (Cyclooxygenase-2)
|9.||Toll-Like Receptor 4