Tretinoin FDA Link Generic

An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).

Also Known As:

Retinoic Acid; all-trans-Retinoic Acid; Retin-A; Vitamin A Acid; Vesanoid; Tretinoin Potassium Salt; Tretinoin Sodium Salt; Tretinoin Zinc Salt; beta-all-trans-Retinoic Acid; trans-Retinoic Acid; Acid, Retinoic; Acid, Vitamin A; Acid, all-trans-Retinoic; Acid, beta-all-trans-Retinoic; Acid, trans-Retinoic; Potassium Salt, Tretinoin; Retin A; Salt, Tretinoin Potassium; Salt, Tretinoin Sodium; Salt, Tretinoin Zinc; Sodium Salt, Tretinoin; Zinc Salt, Tretinoin; all trans Retinoic Acid; beta all trans Retinoic Acid; trans Retinoic Acid

Pharmalogical Action Categories:

Antineoplastic Agents
Keratolytic Agents

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Carotenoids: 4095
      - Retinoids: 5957
        Vitamin A: 9071
        Tretinoin: 11074
    - Diterpenes: 1470
      - Vitamin A: 9071
        Tretinoin: 11074
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclohexanes: 3
        Cyclohexenes: 4
        Carotenoids: 4095
        Retinoids: 5957
        Vitamin A: 9071
        Tretinoin: 11074
  - Acyclic Hydrocarbons
    - Alkenes: 265
      - Polyenes: 164
        Carotenoids: 4095
        Retinoids: 5957
        Vitamin A: 9071
        Tretinoin: 11074
Biological Factors: 2472
- Biological Pigments: 1
  - Carotenoids: 4095
    - Retinoids: 5957
      - Tretinoin: 11074

1.	Leukemia 04/01/1989 - "By using soft agar colony-forming assay, a monoclonal subline of human promyelocytic leukemia HL-60 cells was isolated and inducing activity of differentiation of a new retinoid R-81001 on the cells was studied. "

N-(4-aminosulfonylphenyl)retinamide

Bio-Agent Context: Research Results

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